Poon SF - Search Results

1

3-[3-Fluoro-5-(5-pyridin-2-yl-2H-tetrazol-2-yl)phenyl]-4-methylpyridine: a highly potent and orally bioavailable metabotropic glutamate subtype 5 (mGlu5) receptor antagonist.

Poon SF, Eastman BW, Chapman DF, Chung J, Cramer M, Holtz G, Cosford ND, Smith ND. Poon SF, et al. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5477-80. doi: 10.1016/j.bmcl.2004.09.011. Bioorg Med Chem Lett. 2004. PMID: 15482907

2

Expedited SAR study of an mGluR5 antagonists: generation of a focused library using a solution-phase Suzuki coupling methodology.

Eastman B, Chen C, Smith ND, Poon S, Chung J, Reyes-Manalo G, Cosford ND, Munoz B. Eastman B, et al. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5485-8. doi: 10.1016/j.bmcl.2004.09.016. Bioorg Med Chem Lett. 2004. PMID: 15482909

3

2-(2-[3-(pyridin-3-yloxy)phenyl]-2H-tetrazol-5-yl) pyridine: a highly potent, orally active, metabotropic glutamate subtype 5 (mGlu5) receptor antagonist.

Huang D, Poon SF, Chapman DF, Chung J, Cramer M, Reger TS, Roppe JR, Tehrani L, Cosford ND, Smith ND. Huang D, et al. Among authors: poon sf. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5473-6. doi: 10.1016/j.bmcl.2004.09.012. Bioorg Med Chem Lett. 2004. PMID: 15482906

4

Discovery of highly potent, selective, orally bioavailable, metabotropic glutamate subtype 5 (mGlu5) receptor antagonists devoid of cytochrome P450 1A2 inhibitory activity.

Smith ND, Poon SF, Huang D, Green M, King C, Tehrani L, Roppe JR, Chung J, Chapman DP, Cramer M, Cosford ND. Smith ND, et al. Among authors: poon sf. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5481-4. doi: 10.1016/j.bmcl.2004.09.018. Bioorg Med Chem Lett. 2004. PMID: 15482908

5

3-[Substituted]-5-(5-pyridin-2-yl-2H-tetrazol-2-yl)benzonitriles: identification of highly potent and selective metabotropic glutamate subtype 5 receptor antagonists.

Tehrani LR, Smith ND, Huang D, Poon SF, Roppe JR, Seiders TJ, Chapman DF, Chung J, Cramer M, Cosford ND. Tehrani LR, et al. Among authors: poon sf. Bioorg Med Chem Lett. 2005 Nov 15;15(22):5061-4. doi: 10.1016/j.bmcl.2005.07.062. Epub 2005 Sep 23. Bioorg Med Chem Lett. 2005. PMID: 16183275

6

Novel approach to pro-drugs of lactones: water soluble imidate and ortho-ester derivatives of a furanone-based COX-2 selective inhibitor.

Poon SF, Stock N, Payne JE, McGuire AR, Stearns B, Yang X, Chen W, Munoz B, Smith ND. Poon SF, et al. Bioorg Med Chem Lett. 2005 May 2;15(9):2259-63. doi: 10.1016/j.bmcl.2005.03.009. Bioorg Med Chem Lett. 2005. PMID: 15837305

7

The discovery of an orally efficacious positive allosteric modulator of the calcium sensing receptor containing a dibenzylamine core.

Harrington PE, St Jean DJ Jr, Clarine J, Coulter TS, Croghan M, Davenport A, Davis J, Ghiron C, Hutchinson J, Kelly MG, Lott F, Lu JY, Martin D, Morony S, Poon SF, Portero-Larragueta E, Reagan JD, Regal KA, Tasker A, Wang M, Yang Y, Yao G, Zeng Q, Henley C 3rd, Fotsch C. Harrington PE, et al. Among authors: poon sf. Bioorg Med Chem Lett. 2010 Sep 15;20(18):5544-7. doi: 10.1016/j.bmcl.2010.07.060. Epub 2010 Aug 12. Bioorg Med Chem Lett. 2010. PMID: 20708930

8

Metabolism-guided discovery of a potent and orally bioavailable urea-based calcimimetic for the treatment of secondary hyperparathyroidism.

Wehn PM, Harrington PE, Carlson TJ, Davis J, Deprez P, Fotsch CH, Grillo MP, Lu JY, Morony S, Pattabiraman K, Poon SF, Reagan JD, St Jean DJ Jr, Temal T, Wang M, Yang Y, Henley C 3rd, Lively SE. Wehn PM, et al. Among authors: poon sf. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6625-8. doi: 10.1016/j.bmcl.2013.10.050. Epub 2013 Oct 31. Bioorg Med Chem Lett. 2013. PMID: 24215889

9

Design and synthesis of novel amide AKT1 inhibitors with selectivity over CDK2.

Ashton KS, St Jean DJ Jr, Poon SF, Lee MR, Allen JG, Zhang S, Lofgren JA, Zhang X, Fotsch C, Hungate R. Ashton KS, et al. Among authors: poon sf. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5191-6. doi: 10.1016/j.bmcl.2011.07.056. Epub 2011 Jul 23. Bioorg Med Chem Lett. 2011. PMID: 21824779

10

Discovery and optimization of substituted 1-(1-phenyl-1H-pyrazol-3-yl)methanamines as potent and efficacious type II calcimimetics.

Poon SF, St Jean DJ Jr, Harrington PE, Henley C 3rd, Davis J, Morony S, Lott FD, Reagan JD, Lu JY, Yang Y, Fotsch C. Poon SF, et al. J Med Chem. 2009 Nov 12;52(21):6535-8. doi: 10.1021/jm9012278. J Med Chem. 2009. PMID: 19835382

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