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Page 1
Cetirizine and loratadine-based antihistamines with 5-lipoxygenase inhibitory activity.
Lewis TA, Young MA, Arrington MP, Bayless L, Cai X, Collart P, Eckman JB, Ellis JL, Ene DG, Libertine L, Nicolas JM, Scannell RT, Wels BF, Wenberg K, Wypij DM. Lewis TA, et al. Among authors: eckman jb. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5591-4. doi: 10.1016/j.bmcl.2004.08.060. Bioorg Med Chem Lett. 2004. PMID: 15482930
5-lipoxygenase inhibitors with histamine H(1) receptor antagonist activity.
Lewis TA, Bayless L, Eckman JB, Ellis JL, Grewal G, Libertine L, Marie Nicolas J, Scannell RT, Wels BF, Wenberg K, Wypij DM. Lewis TA, et al. Among authors: eckman jb. Bioorg Med Chem Lett. 2004 May 3;14(9):2265-8. doi: 10.1016/j.bmcl.2004.02.005. Bioorg Med Chem Lett. 2004. PMID: 15081022
Novel dual acting molecules possessing 5-lipoxygenase enzyme inhibition and histamine H(1) receptor antagonist properties.
Scannell RT, Arrington MP, Bayless L, Cai X, Eckman JB, Eckert M, Ene DG, Ellis JL, Hussoin S, Latham GM, Lewis TA, Libertine L, Nicolas J, Selig WM, Schwartz CE, Wels BF, Wypij DM, Young MA, Zou D. Scannell RT, et al. Among authors: eckman jb. Inflamm Res. 2004 Mar;53 Suppl 1:S33-4. doi: 10.1007/s00011-003-0315-4. Epub 2004 Mar 5. Inflamm Res. 2004. PMID: 15054606 No abstract available.
(+/-)-trans-2-[3-methoxy-4-(4-chlorophenylthioethoxy)-5-(N-methyl-N- hydroxyureidyl)methylphenyl]-5-(3,4, 5-trimethoxyphenyl)tetrahydrofuran (CMI-392), a potent dual 5-lipoxygenase inhibitor and platelet-activating factor receptor antagonist.
Cai X, Scannell RT, Yaeger D, Hussoin MS, Killian DB, Qian C, Eckman J, Hwang SB, Libertine-Garahan L, Yeh CG, Ip SH, Shen TY. Cai X, et al. J Med Chem. 1998 May 21;41(11):1970-9. doi: 10.1021/jm980046r. J Med Chem. 1998. PMID: 9599246
Optimization of the in vitro cardiac safety of hydroxamate-based histone deacetylase inhibitors.
Shultz MD, Cao X, Chen CH, Cho YS, Davis NR, Eckman J, Fan J, Fekete A, Firestone B, Flynn J, Green J, Growney JD, Holmqvist M, Hsu M, Jansson D, Jiang L, Kwon P, Liu G, Lombardo F, Lu Q, Majumdar D, Meta C, Perez L, Pu M, Ramsey T, Remiszewski S, Skolnik S, Traebert M, Urban L, Uttamsingh V, Wang P, Whitebread S, Whitehead L, Yan-Neale Y, Yao YM, Zhou L, Atadja P. Shultz MD, et al. J Med Chem. 2011 Jul 14;54(13):4752-72. doi: 10.1021/jm200388e. Epub 2011 Jun 17. J Med Chem. 2011. PMID: 21650221
Epibatidine is a nicotinic analgesic.
Qian C, Li T, Shen TY, Libertine-Garahan L, Eckman J, Biftu T, Ip S. Qian C, et al. Eur J Pharmacol. 1993 Dec 21;250(3):R13-4. doi: 10.1016/0014-2999(93)90043-h. Eur J Pharmacol. 1993. PMID: 8112391
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