Njoroge FG - Search Results

1

Novel 2-oxoimidazolidine-4-carboxylic acid derivatives as hepatitis C virus NS3-4A serine protease inhibitors: synthesis, activity, and X-ray crystal structure of an enzyme inhibitor complex.

Arasappan A, Njoroge FG, Parekh TN, Yang X, Pichardo J, Butkiewicz N, Prongay A, Yao N, Girijavallabhan V. Arasappan A, et al. Among authors: njoroge fg. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5751-5. doi: 10.1016/j.bmcl.2004.09.058. Bioorg Med Chem Lett. 2004. PMID: 15501035

2

Non-peptidic small-molecule inhibitors of the single-chain hepatitis C virus NS3 protease/NS4A cofactor complex discovered by structure-based NMR screening.

Wyss DF, Arasappan A, Senior MM, Wang YS, Beyer BM, Njoroge FG, McCoy MA. Wyss DF, et al. Among authors: njoroge fg. J Med Chem. 2004 May 6;47(10):2486-98. doi: 10.1021/jm0305117. J Med Chem. 2004. PMID: 15115392

3

Design and synthesis of depeptidized macrocyclic inhibitors of hepatitis C NS3-4A protease using structure-based drug design.

Venkatraman S, Njoroge FG, Girijavallabhan VM, Madison VS, Yao NH, Prongay AJ, Butkiewicz N, Pichardo J. Venkatraman S, et al. Among authors: njoroge fg. J Med Chem. 2005 Aug 11;48(16):5088-91. doi: 10.1021/jm0489556. J Med Chem. 2005. PMID: 16078825

4

Novel inhibitors of the hepatitis C virus NS3 proteinase.

Bennett F, Liu YT, Saksena AK, Arasappan A, Butkiewicz N, Dasmahapatra B, Pichardo JS, Njoroge FG, Patel NM, Huang Y, Yang X. Bennett F, et al. Among authors: njoroge fg. Bioorg Med Chem Lett. 2005 Oct 1;15(19):4275-8. doi: 10.1016/j.bmcl.2005.06.079. Bioorg Med Chem Lett. 2005. PMID: 16087334

5

Synthesis and biological activity of macrocyclic inhibitors of hepatitis C virus (HCV) NS3 protease.

Chen KX, Njoroge FG, Prongay A, Pichardo J, Madison V, Girijavallabhan V. Chen KX, et al. Among authors: njoroge fg. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4475-8. doi: 10.1016/j.bmcl.2005.07.033. Bioorg Med Chem Lett. 2005. PMID: 16112859

6

Design, synthesis, and biological activity of m-tyrosine-based 16- and 17-membered macrocyclic inhibitors of hepatitis C virus NS3 serine protease.

Chen KX, Njoroge FG, Pichardo J, Prongay A, Butkiewicz N, Yao N, Madison V, Girijavallabhan V. Chen KX, et al. Among authors: njoroge fg. J Med Chem. 2005 Oct 6;48(20):6229-35. doi: 10.1021/jm050323b. J Med Chem. 2005. PMID: 16190750

7

Depeptidization efforts on P3-P2' alpha-ketoamide inhibitors of HCV NS3-4A serine protease: effect on HCV replicon activity.

Bogen SL, Ruan S, Liu R, Agrawal S, Pichardo J, Prongay A, Baroudy B, Saksena AK, Girijavallabhan V, Njoroge FG. Bogen SL, et al. Among authors: njoroge fg. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1621-7. doi: 10.1016/j.bmcl.2005.12.013. Epub 2006 Jan 4. Bioorg Med Chem Lett. 2006. PMID: 16387495

8

Novel inhibitors of hepatitis C NS3-NS4A serine protease derived from 2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid.

Venkatraman S, Njoroge FG, Wu W, Girijavallabhan V, Prongay AJ, Butkiewicz N, Pichardo J. Venkatraman S, et al. Among authors: njoroge fg. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1628-32. doi: 10.1016/j.bmcl.2005.12.046. Epub 2006 Jan 18. Bioorg Med Chem Lett. 2006. PMID: 16413182

9

Potent 7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid-based macrocyclic inhibitors of hepatitis C virus NS3 protease.

Chen KX, Njoroge FG, Pichardo J, Prongay A, Butkiewicz N, Yao N, Madison V, Girijavallabhan V. Chen KX, et al. Among authors: njoroge fg. J Med Chem. 2006 Jan 26;49(2):567-74. doi: 10.1021/jm050520a. J Med Chem. 2006. PMID: 16420042

10

Novel potent hepatitis C virus NS3 serine protease inhibitors derived from proline-based macrocycles.

Chen KX, Njoroge FG, Arasappan A, Venkatraman S, Vibulbhan B, Yang W, Parekh TN, Pichardo J, Prongay A, Cheng KC, Butkiewicz N, Yao N, Madison V, Girijavallabhan V. Chen KX, et al. Among authors: njoroge fg. J Med Chem. 2006 Feb 9;49(3):995-1005. doi: 10.1021/jm050820s. J Med Chem. 2006. PMID: 16451065

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