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Delta-4-androstene-3,17-dione binds androgen receptor, promotes myogenesis in vitro, and increases serum testosterone levels, fat-free mass, and muscle strength in hypogonadal men.
Jasuja R, Ramaraj P, Mac RP, Singh AB, Storer TW, Artaza J, Miller A, Singh R, Taylor WE, Lee ML, Davidson T, Sinha-Hikim I, Gonzalez-Cadavid N, Bhasin S. Jasuja R, et al. Among authors: mac rp. J Clin Endocrinol Metab. 2005 Feb;90(2):855-63. doi: 10.1210/jc.2004-1577. Epub 2004 Nov 2. J Clin Endocrinol Metab. 2005. PMID: 15522925
Effects of testosterone replacement in human immunodeficiency virus-infected women with weight loss.
Choi HH, Gray PB, Storer TW, Calof OM, Woodhouse L, Singh AB, Padero C, Mac RP, Sinha-Hikim I, Shen R, Dzekov J, Dzekov C, Kushnir MM, Rockwood AL, Meikle AW, Lee ML, Hays RD, Bhasin S. Choi HH, et al. Among authors: mac rp. J Clin Endocrinol Metab. 2005 Mar;90(3):1531-41. doi: 10.1210/jc.2004-1677. Epub 2004 Dec 21. J Clin Endocrinol Metab. 2005. PMID: 15613414 Clinical Trial.