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Utility of large-scale transiently transfected cells for cell-based high-throughput screens to identify transient receptor potential channel A1 (TRPA1) antagonists.
Chen J, Lake MR, Sabet RS, Niforatos W, Pratt SD, Cassar SC, Xu J, Gopalakrishnan S, Pereda-Lopez A, Gopalakrishnan M, Holzman TF, Moreland RB, Walter KA, Faltynek CR, Warrior U, Scott VE. Chen J, et al. J Biomol Screen. 2007 Feb;12(1):61-9. doi: 10.1177/1087057106295220. Epub 2006 Nov 12. J Biomol Screen. 2007. PMID: 17099245
Opening ion channels: enzyme at the gate.
Chen J, Gopalakrishnan M. Chen J, et al. ChemMedChem. 2007 May;2(5):625-6. doi: 10.1002/cmdc.200600313. ChemMedChem. 2007. PMID: 17385752 No abstract available.
Pore dilation occurs in TRPA1 but not in TRPM8 channels.
Chen J, Kim D, Bianchi BR, Cavanaugh EJ, Faltynek CR, Kym PR, Reilly RM. Chen J, et al. Mol Pain. 2009 Jan 21;5:3. doi: 10.1186/1744-8069-5-3. Mol Pain. 2009. PMID: 19159452 Free PMC article.
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