Yang W - Search Results

1

In vivo mechanisms of tissue-selective drug toxicity: effects of liver-specific knockout of the NADPH-cytochrome P450 reductase gene on acetaminophen toxicity in kidney, lung, and nasal mucosa.

Gu J, Cui H, Behr M, Zhang L, Zhang QY, Yang W, Hinson JA, Ding X. Gu J, et al. Among authors: yang w. Mol Pharmacol. 2005 Mar;67(3):623-30. doi: 10.1124/mol.104.007898. Epub 2004 Nov 18. Mol Pharmacol. 2005. PMID: 15550675

2

Liver-specific deletion of the NADPH-cytochrome P450 reductase gene: impact on plasma cholesterol homeostasis and the function and regulation of microsomal cytochrome P450 and heme oxygenase.

Gu J, Weng Y, Zhang QY, Cui H, Behr M, Wu L, Yang W, Zhang L, Ding X. Gu J, et al. Among authors: yang w. J Biol Chem. 2003 Jul 11;278(28):25895-901. doi: 10.1074/jbc.M303125200. Epub 2003 Apr 15. J Biol Chem. 2003. PMID: 12697746 Free article.

3

Transgenic mice with a hypomorphic NADPH-cytochrome P450 reductase gene: effects on development, reproduction, and microsomal cytochrome P450.

Wu L, Gu J, Cui H, Zhang QY, Behr M, Fang C, Weng Y, Kluetzman K, Swiatek PJ, Yang W, Kaminsky L, Ding X. Wu L, et al. Among authors: yang w. J Pharmacol Exp Ther. 2005 Jan;312(1):35-43. doi: 10.1124/jpet.104.073353. Epub 2004 Aug 24. J Pharmacol Exp Ther. 2005. PMID: 15328377

4

Generation and characterization of a transgenic mouse model with hepatic expression of human CYP2A6.

Zhang QY, Gu J, Su T, Cui H, Zhang X, D'Agostino J, Zhuo X, Yang W, Swiatek PJ, Ding X. Zhang QY, et al. Among authors: yang w. Biochem Biophys Res Commun. 2005 Dec 9;338(1):318-24. doi: 10.1016/j.bbrc.2005.08.086. Epub 2005 Aug 22. Biochem Biophys Res Commun. 2005. PMID: 16126166

5

A mouse model with liver-specific deletion and global suppression of the NADPH-cytochrome P450 reductase gene: characterization and utility for in vivo studies of cyclophosphamide disposition.

Gu J, Chen CS, Wei Y, Fang C, Xie F, Kannan K, Yang W, Waxman DJ, Ding X. Gu J, et al. Among authors: yang w. J Pharmacol Exp Ther. 2007 Apr;321(1):9-17. doi: 10.1124/jpet.106.118240. Epub 2007 Jan 11. J Pharmacol Exp Ther. 2007. PMID: 17218484

6

Mechanism of chloroform-induced renal toxicity: non-involvement of hepatic cytochrome P450-dependent metabolism.

Fang C, Behr M, Xie F, Lu S, Doret M, Luo H, Yang W, Aldous K, Ding X, Gu J. Fang C, et al. Among authors: yang w. Toxicol Appl Pharmacol. 2008 Feb 15;227(1):48-55. doi: 10.1016/j.taap.2007.10.014. Epub 2007 Oct 23. Toxicol Appl Pharmacol. 2008. PMID: 18031782 Free PMC article.

7

Deletion of the NADPH-cytochrome P450 reductase gene in cardiomyocytes does not protect mice against doxorubicin-mediated acute cardiac toxicity.

Fang C, Gu J, Xie F, Behr M, Yang W, Abel ED, Ding X. Fang C, et al. Among authors: yang w. Drug Metab Dispos. 2008 Aug;36(8):1722-8. doi: 10.1124/dmd.108.021881. Epub 2008 May 7. Drug Metab Dispos. 2008. PMID: 18463197 Free PMC article.

8

Opioids activate brain analgesic circuits through cytochrome P450/epoxygenase signaling.

Conroy JL, Fang C, Gu J, Zeitlin SO, Yang W, Yang J, VanAlstine MA, Nalwalk JW, Albrecht PJ, Mazurkiewicz JE, Snyder-Keller A, Shan Z, Zhang SZ, Wentland MP, Behr M, Knapp BI, Bidlack JM, Zuiderveld OP, Leurs R, Ding X, Hough LB. Conroy JL, et al. Among authors: yang w, yang j. Nat Neurosci. 2010 Mar;13(3):284-6. doi: 10.1038/nn.2497. Epub 2010 Feb 7. Nat Neurosci. 2010. PMID: 20139973 Free PMC article.

9

Generation of a mouse model with a reversible hypomorphic cytochrome P450 reductase gene: utility for tissue-specific rescue of the reductase expression, and insights from a resultant mouse model with global suppression of P450 reductase expression in extrahepatic tissues.

Wei Y, Zhou X, Fang C, Li L, Kluetzman K, Yang W, Zhang QY, Ding X. Wei Y, et al. Among authors: yang w. J Pharmacol Exp Ther. 2010 Jul;334(1):69-77. doi: 10.1124/jpet.110.167411. Epub 2010 Apr 7. J Pharmacol Exp Ther. 2010. PMID: 20375200 Free PMC article.

10

Brain P450 epoxygenase activity is required for the antinociceptive effects of improgan, a nonopioid analgesic.

Hough LB, Nalwalk JW, Yang J, Conroy JL, VanAlstine MA, Yang W, Gargano J, Shan Z, Zhang SZ, Wentland MP, Phillips JG, Knapp BI, Bidlack JM, Zuiderveld OP, Leurs R, Ding X. Hough LB, et al. Among authors: yang w, yang j. Pain. 2011 Apr;152(4):878-887. doi: 10.1016/j.pain.2011.01.001. Pain. 2011. PMID: 21316152 Free PMC article.

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