Light D - Search Results

1

A model of the acid sphingomyelinase phosphoesterase domain based on its remote structural homolog purple acid phosphatase.

Seto M, Whitlow M, McCarrick MA, Srinivasan S, Zhu Y, Pagila R, Mintzer R, Light D, Johns A, Meurer-Ogden JA. Seto M, et al. Among authors: light d. Protein Sci. 2004 Dec;13(12):3172-86. doi: 10.1110/ps.04966204. Protein Sci. 2004. PMID: 15557261 Free PMC article.

2

The structure of a 19-residue fragment from the C-loop of the fourth epidermal growth factor-like domain of thrombomodulin.

Adler M, Seto MH, Nitecki DE, Lin JH, Light DR, Morser J. Adler M, et al. Among authors: light dr. J Biol Chem. 1995 Oct 6;270(40):23366-72. doi: 10.1074/jbc.270.40.23366. J Biol Chem. 1995. PMID: 7559494 Free article.

3

Crystal structures of two potent nonamidine inhibitors bound to factor Xa.

Adler M, Kochanny MJ, Ye B, Rumennik G, Light DR, Biancalana S, Whitlow M. Adler M, et al. Biochemistry. 2002 Dec 31;41(52):15514-23. doi: 10.1021/bi0264061. Biochemistry. 2002. PMID: 12501180

4

Crystallographic analysis of potent and selective factor Xa inhibitors complexed to bovine trypsin.

Whitlow M, Arnaiz DO, Buckman BO, Davey DD, Griedel B, Guilford WJ, Koovakkat SK, Liang A, Mohan R, Phillips GB, Seto M, Shaw KJ, Xu W, Zhao Z, Light DR, Morrissey MM. Whitlow M, et al. Among authors: light dr. Acta Crystallogr D Biol Crystallogr. 1999 Aug;55(Pt 8):1395-404. doi: 10.1107/s0907444999007350. Acta Crystallogr D Biol Crystallogr. 1999. PMID: 10417407

5

Synthesis, characterization, and structure-activity relationships of amidine-substituted (bis)benzylidene-cycloketone olefin isomers as potent and selective factor Xa inhibitors.

Guilford WJ, Shaw KJ, Dallas JL, Koovakkat S, Lee W, Liang A, Light DR, McCarrick MA, Whitlow M, Ye B, Morrissey MM. Guilford WJ, et al. Among authors: light dr. J Med Chem. 1999 Dec 30;42(26):5415-25. doi: 10.1021/jm990456v. J Med Chem. 1999. PMID: 10639283

6

Preparation, characterization, and the crystal structure of the inhibitor ZK-807834 (CI-1031) complexed with factor Xa.

Adler M, Davey DD, Phillips GB, Kim SH, Jancarik J, Rumennik G, Light DR, Whitlow M. Adler M, et al. Among authors: light dr. Biochemistry. 2000 Oct 17;39(41):12534-42. doi: 10.1021/bi001477q. Biochemistry. 2000. PMID: 11027132

7

(Z,Z)-2,7-Bis(4-amidinobenzylidene)cycloheptan-1-one: identification of a highly active inhibitor of blood coagulation factor Xa.

Shaw KJ, Guilford WJ, Dallas JL, Koovakkaat SK, McCarrick MA, Liang A, Light DR, Morrissey MM. Shaw KJ, et al. Among authors: light dr. J Med Chem. 1998 Sep 10;41(19):3551-6. doi: 10.1021/jm980281+. J Med Chem. 1998. PMID: 9733479 No abstract available.

8

Antibodies neutralizing hepsin protease activity do not impact cell growth but inhibit invasion of prostate and ovarian tumor cells in culture.

Xuan JA, Schneider D, Toy P, Lin R, Newton A, Zhu Y, Finster S, Vogel D, Mintzer B, Dinter H, Light D, Parry R, Polokoff M, Whitlow M, Wu Q, Parry G. Xuan JA, et al. Among authors: light d. Cancer Res. 2006 Apr 1;66(7):3611-9. doi: 10.1158/0008-5472.CAN-05-2983. Cancer Res. 2006. PMID: 16585186

9

Identification of orally bioavailable, non-amidine inhibitors of Urokinase Plasminogen Activator (uPA).

West CW, Adler M, Arnaiz D, Chen D, Chu K, Gualtieri G, Ho E, Huwe C, Light D, Phillips G, Pulk R, Sukovich D, Whitlow M, Yuan S, Bryant J. West CW, et al. Among authors: light d. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5712-5. doi: 10.1016/j.bmcl.2009.08.008. Epub 2009 Aug 7. Bioorg Med Chem Lett. 2009. PMID: 19703768

10

An inhibitor of activated thrombin-activatable fibrinolysis inhibitor potentiates tissue-type plasminogen activator-induced thrombolysis in a rabbit jugular vein thrombolysis model.

Nagashima M, Werner M, Wang M, Zhao L, Light DR, Pagila R, Morser J, Verhallen P. Nagashima M, et al. Among authors: light dr. Thromb Res. 2000 May 15;98(4):333-42. doi: 10.1016/s0049-3848(00)00184-5. Thromb Res. 2000. PMID: 10822080

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