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Sorbitol activates atypical protein kinase C and GLUT4 glucose transporter translocation/glucose transport through proline-rich tyrosine kinase-2, the extracellular signal-regulated kinase pathway and phospholipase D.
Sajan MP, Bandyopadhyay G, Kanoh Y, Standaert ML, Quon MJ, Reed BC, Dikic I, Farese RV. Sajan MP, et al. Among authors: bandyopadhyay g. Biochem J. 2002 Mar 15;362(Pt 3):665-74. doi: 10.1042/0264-6021:3620665. Biochem J. 2002. PMID: 11879194 Free PMC article.
Activation of protein kinase C-zeta by insulin and phosphatidylinositol-3,4,5-(PO4)3 is defective in muscle in type 2 diabetes and impaired glucose tolerance: amelioration by rosiglitazone and exercise.
Beeson M, Sajan MP, Dizon M, Grebenev D, Gomez-Daspet J, Miura A, Kanoh Y, Powe J, Bandyopadhyay G, Standaert ML, Farese RV. Beeson M, et al. Among authors: bandyopadhyay g. Diabetes. 2003 Aug;52(8):1926-34. doi: 10.2337/diabetes.52.8.1926. Diabetes. 2003. PMID: 12882907 Clinical Trial.
173 results