Rosenthal PJ - Search Results

1

Discovery of potent thiosemicarbazone inhibitors of rhodesain and cruzain.

Fujii N, Mallari JP, Hansell EJ, Mackey Z, Doyle P, Zhou YM, Gut J, Rosenthal PJ, McKerrow JH, Guy RK. Fujii N, et al. Among authors: rosenthal pj. Bioorg Med Chem Lett. 2005 Jan 3;15(1):121-3. doi: 10.1016/j.bmcl.2004.10.023. Bioorg Med Chem Lett. 2005. PMID: 15582423

2

Folding of the Plasmodium falciparum cysteine protease falcipain-2 is mediated by a chaperone-like peptide and not the prodomain.

Sijwali PS, Shenai BR, Rosenthal PJ. Sijwali PS, et al. Among authors: rosenthal pj. J Biol Chem. 2002 Apr 26;277(17):14910-5. doi: 10.1074/jbc.M109680200. Epub 2002 Feb 4. J Biol Chem. 2002. PMID: 11827964 Free article.

3

Hydrolysis of erythrocyte proteins by proteases of malaria parasites.

Rosenthal PJ. Rosenthal PJ. Curr Opin Hematol. 2002 Mar;9(2):140-5. doi: 10.1097/00062752-200203000-00010. Curr Opin Hematol. 2002. PMID: 11844998 Review.

4

Stage-specific antimalarial activity of cysteine protease inhibitors.

Shenai BR, Semenov AV, Rosenthal PJ. Shenai BR, et al. Among authors: rosenthal pj. Biol Chem. 2002 May;383(5):843-7. doi: 10.1515/BC.2002.089. Biol Chem. 2002. PMID: 12108550

5

Cysteine proteases of malaria parasites: targets for chemotherapy.

Rosenthal PJ, Sijwali PS, Singh A, Shenai BR. Rosenthal PJ, et al. Curr Pharm Des. 2002;8(18):1659-72. doi: 10.2174/1381612023394197. Curr Pharm Des. 2002. PMID: 12132997 Review.

6

Critical role of amino acid 23 in mediating activity and specificity of vinckepain-2, a papain-family cysteine protease of rodent malaria parasites.

Singh A, Shenai BR, Choe Y, Gut J, Sijwali PS, Craik CS, Rosenthal PJ. Singh A, et al. Among authors: rosenthal pj. Biochem J. 2002 Nov 15;368(Pt 1):273-81. doi: 10.1042/BJ20020753. Biochem J. 2002. PMID: 12169096 Free PMC article.

7

Structure-activity relationships for inhibition of cysteine protease activity and development of Plasmodium falciparum by peptidyl vinyl sulfones.

Shenai BR, Lee BJ, Alvarez-Hernandez A, Chong PY, Emal CD, Neitz RJ, Roush WR, Rosenthal PJ. Shenai BR, et al. Among authors: rosenthal pj. Antimicrob Agents Chemother. 2003 Jan;47(1):154-60. doi: 10.1128/AAC.47.1.154-160.2003. Antimicrob Agents Chemother. 2003. PMID: 12499184 Free PMC article.

8

Structure-based approach to falcipain-2 inhibitors: synthesis and biological evaluation of 1,6,7-trisubstituted dihydroisoquinolines and isoquinolines.

Batra S, Sabnis YA, Rosenthal PJ, Avery MA. Batra S, et al. Among authors: rosenthal pj. Bioorg Med Chem. 2003 May 15;11(10):2293-9. doi: 10.1016/s0968-0896(03)00117-2. Bioorg Med Chem. 2003. PMID: 12713840

9

Synthesis and evaluation of isatins and thiosemicarbazone derivatives against cruzain, falcipain-2 and rhodesain.

Chiyanzu I, Hansell E, Gut J, Rosenthal PJ, McKerrow JH, Chibale K. Chiyanzu I, et al. Among authors: rosenthal pj. Bioorg Med Chem Lett. 2003 Oct 20;13(20):3527-30. doi: 10.1016/s0960-894x(03)00756-x. Bioorg Med Chem Lett. 2003. PMID: 14505663

10

Independent intramolecular mediators of folding, activity, and inhibition for the Plasmodium falciparum cysteine protease falcipain-2.

Pandey KC, Sijwali PS, Singh A, Na BK, Rosenthal PJ. Pandey KC, et al. Among authors: rosenthal pj. J Biol Chem. 2004 Jan 30;279(5):3484-91. doi: 10.1074/jbc.M310536200. Epub 2003 Nov 18. J Biol Chem. 2004. PMID: 14625277 Free article.

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