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The length of lipids bound to human CD1d molecules modulates the affinity of NKT cell TCR and the threshold of NKT cell activation.
McCarthy C, Shepherd D, Fleire S, Stronge VS, Koch M, Illarionov PA, Bossi G, Salio M, Denkberg G, Reddington F, Tarlton A, Reddy BG, Schmidt RR, Reiter Y, Griffiths GM, van der Merwe PA, Besra GS, Jones EY, Batista FD, Cerundolo V. McCarthy C, et al. Among authors: shepherd d. J Exp Med. 2007 May 14;204(5):1131-44. doi: 10.1084/jem.20062342. Epub 2007 May 7. J Exp Med. 2007. PMID: 17485514 Free PMC article.
These data are consistent with previously described conformational changes between empty and loaded hCD1d molecules (Koch, M., V.S. Stronge, D. Shepherd, S.D. Gadola, B. Mathew, G. Ritter, A.R. Fersht, G.S. Besra, R.R. Schmidt, E.Y. ...
These data are consistent with previously described conformational changes between empty and loaded hCD1d molecules (Koch, M., V.S. Stronge, …
Generation of CD1 tetramers as a tool to monitor glycolipid-specific T cells.
Gadola SD, Karadimitris A, Zaccai NR, Salio M, Dulphy N, Shepherd D, Jones EY, Cerundolo V. Gadola SD, et al. Among authors: shepherd d. Philos Trans R Soc Lond B Biol Sci. 2003 May 29;358(1433):875-7. doi: 10.1098/rstb.2003.1267. Philos Trans R Soc Lond B Biol Sci. 2003. PMID: 12803920 Free PMC article. Review.
Saposins modulate human invariant Natural Killer T cells self-reactivity and facilitate lipid exchange with CD1d molecules during antigen presentation.
Salio M, Ghadbane H, Dushek O, Shepherd D, Cypen J, Gileadi U, Aichinger MC, Napolitani G, Qi X, van der Merwe PA, Wojno J, Veerapen N, Cox LR, Besra GS, Yuan W, Cresswell P, Cerundolo V. Salio M, et al. Among authors: shepherd d. Proc Natl Acad Sci U S A. 2013 Dec 3;110(49):E4753-61. doi: 10.1073/pnas.1310050110. Epub 2013 Nov 18. Proc Natl Acad Sci U S A. 2013. PMID: 24248359 Free PMC article.
Essential role for autophagy during invariant NKT cell development.
Salio M, Puleston DJ, Mathan TS, Shepherd D, Stranks AJ, Adamopoulou E, Veerapen N, Besra GS, Hollander GA, Simon AK, Cerundolo V. Salio M, et al. Among authors: shepherd d. Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):E5678-87. doi: 10.1073/pnas.1413935112. Epub 2014 Dec 15. Proc Natl Acad Sci U S A. 2014. PMID: 25512546 Free PMC article.
882 results