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Page 1
Novel interactions of large P3 moiety and small P4 moiety in the binding of the peptide mimetic factor VIIa inhibitor.
Kadono S, Sakamoto A, Kikuchi Y, Oh-Eda M, Yabuta N, Yoshihashi K, Kitazawa T, Suzuki T, Koga T, Hattori K, Shiraishi T, Haramura M, Kodama H, Ono Y, Esaki T, Sato H, Watanabe Y, Itoh S, Ohta M, Kozono T. Kadono S, et al. Among authors: haramura m. Biochem Biophys Res Commun. 2005 Jan 28;326(4):859-65. doi: 10.1016/j.bbrc.2004.11.108. Biochem Biophys Res Commun. 2005. PMID: 15607748
Structure-based design of P3 moieties in the peptide mimetic factor VIIa inhibitor.
Kadono S, Sakamoto A, Kikuchi Y, Oh-eda M, Yabuta N, Yoshihashi K, Kitazawa T, Suzuki T, Koga T, Hattori K, Shiraishi T, Haramura M, Kodama H, Ono Y, Esaki T, Sato H, Watanabe Y, Itoh S, Ohta M, Kozono T. Kadono S, et al. Among authors: haramura m. Biochem Biophys Res Commun. 2005 Feb 11;327(2):589-96. doi: 10.1016/j.bbrc.2004.12.042. Biochem Biophys Res Commun. 2005. PMID: 15629154
Structure of human factor VIIa/tissue factor in complex with a peptide-mimetic inhibitor: high selectivity against thrombin by introducing two charged groups in P2 and P4.
Kadono S, Sakamoto A, Kikuchi Y, Oh-Eda M, Yabuta N, Koga T, Hattori K, Shiraishi T, Haramura M, Kodama H, Ono Y, Esaki T, Sato H, Watanabe Y, Itoh S, Ohta M, Kozono T. Kadono S, et al. Among authors: haramura m. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Feb 1;61(Pt 2):169-73. doi: 10.1107/S1744309105000047. Epub 2005 Jan 20. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005. PMID: 16510984 Free PMC article.
Factor VIIa inhibitors: target hopping in the serine protease family using X-ray structure determination.
Shiraishi T, Kadono S, Haramura M, Kodama H, Ono Y, Iikura H, Esaki T, Koga T, Hattori K, Watanabe Y, Sakamoto A, Yoshihashi K, Kitazawa T, Esaki K, Ohta M, Sato H, Kozono T. Shiraishi T, et al. Among authors: haramura m. Bioorg Med Chem Lett. 2008 Aug 15;18(16):4533-7. doi: 10.1016/j.bmcl.2008.07.044. Epub 2008 Jul 16. Bioorg Med Chem Lett. 2008. PMID: 18674905
Design and synthesis of peptidomimetic factor VIIa inhibitors.
Shiraishi T, Kadono S, Haramura M, Kodama H, Ono Y, Iikura H, Esaki T, Koga T, Hattori K, Watanabe Y, Sakamoto A, Yoshihashi K, Kitazawa T, Esaki K, Ohta M, Sato H, Kozono T. Shiraishi T, et al. Among authors: haramura m. Chem Pharm Bull (Tokyo). 2010 Jan;58(1):38-44. doi: 10.1248/cpb.58.38. Chem Pharm Bull (Tokyo). 2010. PMID: 20045964 Free article.
Design and synthesis of novel tetra-peptide motilin agonists.
Haramura M, Tsuzuki K, Okamachi A, Yogo K, Ikuta M, Kozono T, Takanashi H, Murayama E. Haramura M, et al. Bioorg Med Chem. 2002 Jun;10(6):1805-11. doi: 10.1016/s0968-0896(02)00027-5. Bioorg Med Chem. 2002. PMID: 11937338
36 results