Sowin TJ - Search Results

1

A novel mechanism of checkpoint abrogation conferred by Chk1 downregulation.

Xiao Z, Xue J, Sowin TJ, Rosenberg SH, Zhang H. Xiao Z, et al. Among authors: sowin tj. Oncogene. 2005 Feb 17;24(8):1403-11. doi: 10.1038/sj.onc.1208309. Oncogene. 2005. PMID: 15608676

2

Human Chk1 expression is dispensable for somatic cell death and critical for sustaining G2 DNA damage checkpoint.

Chen Z, Xiao Z, Chen J, Ng SC, Sowin T, Sham H, Rosenberg S, Fesik S, Zhang H. Chen Z, et al. Mol Cancer Ther. 2003 Jun;2(6):543-8. Mol Cancer Ther. 2003. PMID: 12813133

3

1-(5-Chloro-2-alkoxyphenyl)-3-(5-cyanopyrazin-2-yl)ureas [correction of cyanopyrazi] as potent and selective inhibitors of Chk1 kinase: synthesis, preliminary SAR, and biological activities.

Wang GT, Li G, Mantei RA, Chen Z, Kovar P, Gu W, Xiao Z, Zhang H, Sham HL, Sowin T, Rosenberg SH, Lin NH. Wang GT, et al. J Med Chem. 2005 May 5;48(9):3118-21. doi: 10.1021/jm048989d. J Med Chem. 2005. PMID: 15857116

4

Synthesis and biological evaluation of 4'-(6,7-disubstituted-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-biphenyl-4-ol as potent Chk1 inhibitors.

Tao ZF, Li G, Tong Y, Chen Z, Merta P, Kovar P, Zhang H, Rosenberg SH, Sham HL, Sowin TJ, Lin NH. Tao ZF, et al. Among authors: sowin tj. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4308-15. doi: 10.1016/j.bmcl.2007.05.027. Epub 2007 May 16. Bioorg Med Chem Lett. 2007. PMID: 17544271

5

Discovery of 4'-(1,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-benzonitriles and 4'-(1,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-pyridine-2'-carbonitriles as potent checkpoint kinase 1 (Chk1) inhibitors.

Tao ZF, Li G, Tong Y, Stewart KD, Chen Z, Bui MH, Merta P, Park C, Kovar P, Zhang H, Sham HL, Rosenberg SH, Sowin TJ, Lin NH. Tao ZF, et al. Among authors: sowin tj. Bioorg Med Chem Lett. 2007 Nov 1;17(21):5944-51. doi: 10.1016/j.bmcl.2007.07.102. Epub 2007 Aug 25. Bioorg Med Chem Lett. 2007. PMID: 17827013

6

Investigation of novel 7,8-disubstituted-5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-ones as potent Chk1 inhibitors.

Hasvold LA, Wang L, Przytulinska M, Xiao Z, Chen Z, Gu WZ, Merta PJ, Xue J, Kovar P, Zhang H, Park C, Sowin TJ, Rosenberg SH, Lin NH. Hasvold LA, et al. Among authors: sowin tj. Bioorg Med Chem Lett. 2008 Apr 1;18(7):2311-5. doi: 10.1016/j.bmcl.2008.02.080. Epub 2008 Mar 6. Bioorg Med Chem Lett. 2008. PMID: 18358720

7

Cyclin B1 is an efficacy-predicting biomarker for Chk1 inhibitors.

Xiao Z, Xue J, Gu WZ, Bui M, Li G, Tao ZF, Lin NH, Sowin TJ, Zhang H. Xiao Z, et al. Among authors: sowin tj. Biomarkers. 2008 Sep;13(6):579-96. doi: 10.1080/13547500802063240. Biomarkers. 2008. PMID: 18671143

8

Chk1 mediates S and G2 arrests through Cdc25A degradation in response to DNA-damaging agents.

Xiao Z, Chen Z, Gunasekera AH, Sowin TJ, Rosenberg SH, Fesik S, Zhang H. Xiao Z, et al. Among authors: sowin tj. J Biol Chem. 2003 Jun 13;278(24):21767-73. doi: 10.1074/jbc.M300229200. Epub 2003 Apr 3. J Biol Chem. 2003. PMID: 12676925 Free article.

9

Novel indication for cancer therapy: Chk1 inhibition sensitizes tumor cells to antimitotics.

Xiao Z, Xue J, Semizarov D, Sowin TJ, Rosenberg SH, Zhang H. Xiao Z, et al. Among authors: sowin tj. Int J Cancer. 2005 Jul 1;115(4):528-38. doi: 10.1002/ijc.20770. Int J Cancer. 2005. PMID: 15688426

10

Differential roles of checkpoint kinase 1, checkpoint kinase 2, and mitogen-activated protein kinase-activated protein kinase 2 in mediating DNA damage-induced cell cycle arrest: implications for cancer therapy.

Xiao Z, Xue J, Sowin TJ, Zhang H. Xiao Z, et al. Among authors: sowin tj. Mol Cancer Ther. 2006 Aug;5(8):1935-43. doi: 10.1158/1535-7163.MCT-06-0077. Mol Cancer Ther. 2006. PMID: 16928813

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