Mulcahy JV - Search Results

1

Apolipoprotein E delivery by peritoneal implantation of encapsulated recombinant cells improves the hyperlipidaemic profile in apoE-deficient mice.

Tagalakis AD, Diakonov IA, Graham IR, Heald KA, Harris JD, Mulcahy JV, Dickson G, Owen JS. Tagalakis AD, et al. Among authors: mulcahy jv. Biochim Biophys Acta. 2005 Jan 5;1686(3):190-9. doi: 10.1016/j.bbalip.2004.10.001. Biochim Biophys Acta. 2005. PMID: 15629688

2

ATP-binding cassette A1 protein and HDL homeostasis.

Owen JS, Mulcahy JV. Owen JS, et al. Among authors: mulcahy jv. Atheroscler Suppl. 2002 Dec;3(4):13-22. doi: 10.1016/s1567-5688(02)00043-0. Atheroscler Suppl. 2002. PMID: 12573359 Review.

3

Human scavenger receptor class B type II (SR-BII) and cellular cholesterol efflux.

Mulcahy JV, Riddell DR, Owen JS. Mulcahy JV, et al. Biochem J. 2004 Feb 1;377(Pt 3):741-7. doi: 10.1042/BJ20030307. Biochem J. 2004. PMID: 14570588 Free PMC article.

4

ST-2560, a selective inhibitor of the Na_V1.7 sodium channel, affects nocifensive and cardiovascular reflexes in non-human primates.

Mulcahy JV, Beckley JT, Klas SD, Odink DA, Delwig A, Pajouhesh H, Monteleone D, Zhou X, Du Bois J, Yeomans DC, Luu G, Hunter JC. Mulcahy JV, et al. Br J Pharmacol. 2024 Sep;181(17):3160-3171. doi: 10.1111/bph.16398. Epub 2024 May 7. Br J Pharmacol. 2024. PMID: 38715413

5

Discovery of Selective Inhibitors of Na_V1.7 Templated on Saxitoxin as Therapeutics for Pain.

Pajouhesh H, Delwig A, Beckley JT, Klas S, Monteleone D, Zhou X, Luu G, Du Bois J, Hunter JC, Mulcahy JV. Pajouhesh H, et al. Among authors: mulcahy jv. ACS Med Chem Lett. 2022 Oct 18;13(11):1763-1768. doi: 10.1021/acsmedchemlett.2c00378. eCollection 2022 Nov 10. ACS Med Chem Lett. 2022. PMID: 36385936 Free PMC article.

6

Antinociceptive properties of an isoform-selective inhibitor of Nav1.7 derived from saxitoxin in mouse models of pain.

Beckley JT, Pajouhesh H, Luu G, Klas S, Delwig A, Monteleone D, Zhou X, Giuvelis D, Meng ID, Yeomans DC, Hunter JC, Mulcahy JV. Beckley JT, et al. Among authors: mulcahy jv. Pain. 2021 Apr 1;162(4):1250-1261. doi: 10.1097/j.pain.0000000000002112. Pain. 2021. PMID: 33086288 Free PMC article.

7

Discovery of a selective, state-independent inhibitor of Na_V1.7 by modification of guanidinium toxins.

Pajouhesh H, Beckley JT, Delwig A, Hajare HS, Luu G, Monteleone D, Zhou X, Ligutti J, Amagasu S, Moyer BD, Yeomans DC, Du Bois J, Mulcahy JV. Pajouhesh H, et al. Among authors: mulcahy jv. Sci Rep. 2020 Sep 9;10(1):14791. doi: 10.1038/s41598-020-71135-2. Sci Rep. 2020. PMID: 32908170 Free PMC article.

8

Challenges and Opportunities for Therapeutics Targeting the Voltage-Gated Sodium Channel Isoform Na_V1.7.

Mulcahy JV, Pajouhesh H, Beckley JT, Delwig A, Du Bois J, Hunter JC. Mulcahy JV, et al. J Med Chem. 2019 Oct 10;62(19):8695-8710. doi: 10.1021/acs.jmedchem.8b01906. Epub 2019 May 7. J Med Chem. 2019. PMID: 31012583 Free PMC article. Review.

9

Synthesis of the Paralytic Shellfish Poisons (+)-Gonyautoxin 2, (+)-Gonyautoxin 3, and (+)-11,11-Dihydroxysaxitoxin.

Mulcahy JV, Walker JR, Merit JE, Whitehead A, Du Bois J. Mulcahy JV, et al. J Am Chem Soc. 2016 May 11;138(18):5994-6001. doi: 10.1021/jacs.6b02343. Epub 2016 May 3. J Am Chem Soc. 2016. PMID: 27138488

10

Visualizing dermal permeation of sodium channel modulators by mass spectrometric imaging.

Eberlin LS, Mulcahy JV, Tzabazis A, Zhang J, Liu H, Logan MM, Roberts HJ, Lee GK, Yeomans DC, Du Bois J, Zare RN. Eberlin LS, et al. Among authors: mulcahy jv. J Am Chem Soc. 2014 Apr 30;136(17):6401-5. doi: 10.1021/ja501635u. Epub 2014 Apr 17. J Am Chem Soc. 2014. PMID: 24708172 Free PMC article.

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