Jacobsen H - Search Results

1

Altered metabolic profile in the frontal cortex of PS2APP transgenic mice, monitored throughout their life span.

von Kienlin M, Künnecke B, Metzger F, Steiner G, Richards JG, Ozmen L, Jacobsen H, Loetscher H. von Kienlin M, et al. Among authors: jacobsen h. Neurobiol Dis. 2005 Feb;18(1):32-9. doi: 10.1016/j.nbd.2004.09.005. Neurobiol Dis. 2005. PMID: 15649694

2

Expression of transgenic APP mRNA is the key determinant for beta-amyloid deposition in PS2APP transgenic mice.

Ozmen L, Albientz A, Czech C, Jacobsen H. Ozmen L, et al. Among authors: jacobsen h. Neurodegener Dis. 2009;6(1-2):29-36. doi: 10.1159/000170884. Epub 2008 Nov 5. Neurodegener Dis. 2009. PMID: 19066434

3

PS2APP transgenic mice, coexpressing hPS2mut and hAPPswe, show age-related cognitive deficits associated with discrete brain amyloid deposition and inflammation.

Richards JG, Higgins GA, Ouagazzal AM, Ozmen L, Kew JN, Bohrmann B, Malherbe P, Brockhaus M, Loetscher H, Czech C, Huber G, Bluethmann H, Jacobsen H, Kemp JA. Richards JG, et al. Among authors: jacobsen h. J Neurosci. 2003 Oct 1;23(26):8989-9003. doi: 10.1523/JNEUROSCI.23-26-08989.2003. J Neurosci. 2003. PMID: 14523101 Free PMC article.

4

BACE/APPV717F double-transgenic mice develop cerebral amyloidosis and inflammation.

Ozmen L, Woolley M, Albientz A, Miss MT, Nelboeck P, Malherbe P, Czech C, Gruninger-Leitch F, Brockhaus M, Ballard T, Jacobsen H. Ozmen L, et al. Among authors: jacobsen h. Neurodegener Dis. 2005;2(6):284-98. doi: 10.1159/000092314. Neurodegener Dis. 2005. PMID: 16909011

5

Combined treatment with a BACE inhibitor and anti-Aβ antibody gantenerumab enhances amyloid reduction in APPLondon mice.

Jacobsen H, Ozmen L, Caruso A, Narquizian R, Hilpert H, Jacobsen B, Terwel D, Tanghe A, Bohrmann B. Jacobsen H, et al. Among authors: jacobsen b. J Neurosci. 2014 Aug 27;34(35):11621-30. doi: 10.1523/JNEUROSCI.1405-14.2014. J Neurosci. 2014. PMID: 25164658 Free PMC article.

6

Aminothiazoles as γ-secretase modulators.

Lübbers T, Flohr A, Jolidon S, David-Pierson P, Jacobsen H, Ozmen L, Baumann K. Lübbers T, et al. Among authors: jacobsen h. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6554-8. doi: 10.1016/j.bmcl.2011.08.060. Epub 2011 Aug 19. Bioorg Med Chem Lett. 2011. PMID: 21924610

7

The dynamics of Aβ distribution after γ-secretase inhibitor treatment, as determined by experimental and modelling approaches in a wild type rat.

Tai LM, Jacobsen H, Ozmen L, Flohr A, Jakob-Roetne R, Caruso A, Grimm HP. Tai LM, et al. Among authors: jacobsen h. J Pharmacokinet Pharmacodyn. 2012 Jun;39(3):227-37. doi: 10.1007/s10928-012-9246-4. Epub 2012 Apr 6. J Pharmacokinet Pharmacodyn. 2012. PMID: 22481485

8

Novel orally active, dibenzazepinone-based gamma-secretase inhibitors.

Peters JU, Galley G, Jacobsen H, Czech C, David-Pierson P, Kitas EA, Ozmen L. Peters JU, et al. Among authors: jacobsen h. Bioorg Med Chem Lett. 2007 Nov 1;17(21):5918-23. doi: 10.1016/j.bmcl.2007.07.078. Epub 2007 Aug 22. Bioorg Med Chem Lett. 2007. PMID: 17869099

9

The influence of endoproteolytic processing of familial Alzheimer's disease presenilin 2 on abeta42 amyloid peptide formation.

Jacobsen H, Reinhardt D, Brockhaus M, Bur D, Kocyba C, Kurt H, Grim MG, Baumeister R, Loetscher H. Jacobsen H, et al. J Biol Chem. 1999 Dec 3;274(49):35233-9. doi: 10.1074/jbc.274.49.35233. J Biol Chem. 1999. PMID: 10575009 Free article.

10

Substituted 2-oxo-azepane derivatives are potent, orally active gamma-secretase inhibitors.

Kitas EA, Galley G, Jakob-Roetne R, Flohr A, Wostl W, Mauser H, Alker AM, Czech C, Ozmen L, David-Pierson P, Reinhardt D, Jacobsen H. Kitas EA, et al. Among authors: jacobsen h. Bioorg Med Chem Lett. 2008 Jan 1;18(1):304-8. doi: 10.1016/j.bmcl.2007.10.074. Epub 2007 Nov 5. Bioorg Med Chem Lett. 2008. PMID: 17983746

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