Tickle IJ - Search Results

1

Fragment-based lead discovery using X-ray crystallography.

Hartshorn MJ, Murray CW, Cleasby A, Frederickson M, Tickle IJ, Jhoti H. Hartshorn MJ, et al. Among authors: tickle ij. J Med Chem. 2005 Jan 27;48(2):403-13. doi: 10.1021/jm0495778. J Med Chem. 2005. PMID: 15658854

2

High-throughput protein crystallography and drug discovery.

Tickle I, Sharff A, Vinkovic M, Yon J, Jhoti H. Tickle I, et al. Chem Soc Rev. 2004 Oct 20;33(8):558-65. doi: 10.1039/b314510g. Epub 2004 Sep 20. Chem Soc Rev. 2004. PMID: 15480479

3

Automated protein-ligand crystallography for structure-based drug design.

Mooij WT, Hartshorn MJ, Tickle IJ, Sharff AJ, Verdonk ML, Jhoti H. Mooij WT, et al. Among authors: tickle ij. ChemMedChem. 2006 Aug;1(8):827-38. doi: 10.1002/cmdc.200600074. ChemMedChem. 2006. PMID: 16902937

4

Sensitivity of molecular docking to induced fit effects in influenza virus neuraminidase.

Birch L, Murray CW, Hartshorn MJ, Tickle IJ, Verdonk ML. Birch L, et al. Among authors: tickle ij. J Comput Aided Mol Des. 2002 Dec;16(12):855-69. doi: 10.1023/a:1023844626572. J Comput Aided Mol Des. 2002. PMID: 12825619

5

Crystal structure of human CDK4 in complex with a D-type cyclin.

Day PJ, Cleasby A, Tickle IJ, O'Reilly M, Coyle JE, Holding FP, McMenamin RL, Yon J, Chopra R, Lengauer C, Jhoti H. Day PJ, et al. Among authors: tickle ij. Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4166-70. doi: 10.1073/pnas.0809645106. Epub 2009 Feb 23. Proc Natl Acad Sci U S A. 2009. PMID: 19237565 Free PMC article.

6

Detection of secondary binding sites in proteins using fragment screening.

Ludlow RF, Verdonk ML, Saini HK, Tickle IJ, Jhoti H. Ludlow RF, et al. Among authors: tickle ij. Proc Natl Acad Sci U S A. 2015 Dec 29;112(52):15910-5. doi: 10.1073/pnas.1518946112. Epub 2015 Dec 11. Proc Natl Acad Sci U S A. 2015. PMID: 26655740 Free PMC article.

7

Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone.

Williams PA, Cosme J, Vinkovic DM, Ward A, Angove HC, Day PJ, Vonrhein C, Tickle IJ, Jhoti H. Williams PA, et al. Among authors: tickle ij. Science. 2004 Jul 30;305(5684):683-6. doi: 10.1126/science.1099736. Epub 2004 Jul 15. Science. 2004. PMID: 15256616

8

Structure of a CBS-domain pair from the regulatory gamma1 subunit of human AMPK in complex with AMP and ZMP.

Day P, Sharff A, Parra L, Cleasby A, Williams M, Hörer S, Nar H, Redemann N, Tickle I, Yon J. Day P, et al. Acta Crystallogr D Biol Crystallogr. 2007 May;63(Pt 5):587-96. doi: 10.1107/S0907444907009110. Epub 2007 Apr 21. Acta Crystallogr D Biol Crystallogr. 2007. PMID: 17452784

9

Structure of the BTB domain of Keap1 and its interaction with the triterpenoid antagonist CDDO.

Cleasby A, Yon J, Day PJ, Richardson C, Tickle IJ, Williams PA, Callahan JF, Carr R, Concha N, Kerns JK, Qi H, Sweitzer T, Ward P, Davies TG. Cleasby A, et al. Among authors: tickle ij. PLoS One. 2014 Jun 4;9(6):e98896. doi: 10.1371/journal.pone.0098896. eCollection 2014. PLoS One. 2014. PMID: 24896564 Free PMC article.

10

Fragment screening using X-ray crystallography.

Davies TG, Tickle IJ. Davies TG, et al. Among authors: tickle ij. Top Curr Chem. 2012;317:33-59. doi: 10.1007/128_2011_179. Top Curr Chem. 2012. PMID: 21678136 Review.

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