Shokeer A - Search Results

1

Residue 234 in glutathione transferase T1-1 plays a pivotal role in the catalytic activity and the selectivity against alternative substrates.

Shokeer A, Larsson AK, Mannervik B. Shokeer A, et al. Biochem J. 2005 May 15;388(Pt 1):387-92. doi: 10.1042/BJ20042064. Biochem J. 2005. PMID: 15683365 Free PMC article.

2

Structural basis of the suppressed catalytic activity of wild-type human glutathione transferase T1-1 compared to its W234R mutant.

Tars K, Larsson AK, Shokeer A, Olin B, Mannervik B, Kleywegt GJ. Tars K, et al. Among authors: shokeer a. J Mol Biol. 2006 Jan 6;355(1):96-105. doi: 10.1016/j.jmb.2005.10.049. Epub 2005 Nov 8. J Mol Biol. 2006. PMID: 16298388

3

Structural determinants of glutathione transferases with azathioprine activity identified by DNA shuffling of alpha class members.

Kurtovic S, Modén O, Shokeer A, Mannervik B. Kurtovic S, et al. Among authors: shokeer a. J Mol Biol. 2008 Feb 1;375(5):1365-79. doi: 10.1016/j.jmb.2007.11.034. Epub 2007 Nov 19. J Mol Biol. 2008. PMID: 18155239

4

Diverging catalytic capacities and selectivity profiles with haloalkane substrates of chimeric alpha class glutathione transferases.

Kurtovic S, Shokeer A, Mannervik B. Kurtovic S, et al. Among authors: shokeer a. Protein Eng Des Sel. 2008 May;21(5):329-41. doi: 10.1093/protein/gzn010. Epub 2008 Mar 19. Protein Eng Des Sel. 2008. PMID: 18356169

5

Emergence of novel enzyme quasi-species depends on the substrate matrix.

Kurtovic S, Shokeer A, Mannervik B. Kurtovic S, et al. Among authors: shokeer a. J Mol Biol. 2008 Sep 26;382(1):136-53. doi: 10.1016/j.jmb.2008.07.003. Epub 2008 Jul 9. J Mol Biol. 2008. PMID: 18640124

6

Emergence of a novel highly specific and catalytically efficient enzyme from a naturally promiscuous glutathione transferase.

Blikstad C, Shokeer A, Kurtovic S, Mannervik B. Blikstad C, et al. Among authors: shokeer a. Biochim Biophys Acta. 2008 Dec;1780(12):1458-63. doi: 10.1016/j.bbagen.2008.07.007. Epub 2008 Jul 28. Biochim Biophys Acta. 2008. PMID: 18706975

7

Minor modifications of the C-terminal helix reschedule the favored chemical reactions catalyzed by theta class glutathione transferase T1-1.

Shokeer A, Mannervik B. Shokeer A, et al. J Biol Chem. 2010 Feb 19;285(8):5639-45. doi: 10.1074/jbc.M109.074757. Epub 2009 Dec 18. J Biol Chem. 2010. PMID: 20022951 Free PMC article.

8

Residue 234 is a master switch of the alternative-substrate activity profile of human and rodent theta class glutathione transferase T1-1.

Shokeer A, Mannervik B. Shokeer A, et al. Biochim Biophys Acta. 2010 Apr;1800(4):466-73. doi: 10.1016/j.bbagen.2010.01.003. Epub 2010 Jan 25. Biochim Biophys Acta. 2010. PMID: 20097269

9

Molecular evolution of Theta-class glutathione transferase for enhanced activity with the anticancer drug 1,3-bis-(2-chloroethyl)-1-nitrosourea and other alkylating agents.

Larsson AK, Shokeer A, Mannervik B. Larsson AK, et al. Among authors: shokeer a. Arch Biochem Biophys. 2010 May;497(1-2):28-34. doi: 10.1016/j.abb.2010.03.001. Epub 2010 Mar 4. Arch Biochem Biophys. 2010. PMID: 20211594

10

Revealing of a novel xylose-binding site of Geobacillus stearothermophilus xylanase by directed evolution.

Hegazy UM, El-Khonezy MI, Shokeer A, Abdel-Ghany SS, Bassuny RI, Barakat AZ, Salama WH, Azouz RAM, Fahmy AS. Hegazy UM, et al. Among authors: shokeer a. J Biochem. 2019 Feb 1;165(2):177-184. doi: 10.1093/jb/mvy092. J Biochem. 2019. PMID: 30407509

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