Nicolai E - Search Results

1

De novo design, synthesis, and in vitro activity of LFA-1 antagonists based on a bicyclic[5.5]hydantoin scaffold.

Potin D, Launay M, Nicolai E, Fabreguette M, Malabre P, Caussade F, Besse D, Skala S, Stetsko DK, Todderud G, Beno BR, Cheney DL, Chang CJ, Sheriff S, Hollenbaugh DL, Barrish JC, Iwanowicz EJ, Suchard SJ, Dhar TG. Potin D, et al. Among authors: nicolai e. Bioorg Med Chem Lett. 2005 Feb 15;15(4):1161-4. doi: 10.1016/j.bmcl.2004.12.007. Bioorg Med Chem Lett. 2005. PMID: 15686933

2

Discovery and development of 5-[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non-7-yl-methyl]-3-thiophenecarboxylic acid (BMS-587101)--a small molecule antagonist of leukocyte function associated antigen-1.

Potin D, Launay M, Monatlik F, Malabre P, Fabreguettes M, Fouquet A, Maillet M, Nicolai E, Dorgeret L, Chevallier F, Besse D, Dufort M, Caussade F, Ahmad SZ, Stetsko DK, Skala S, Davis PM, Balimane P, Patel K, Yang Z, Marathe P, Postelneck J, Townsend RM, Goldfarb V, Sheriff S, Einspahr H, Kish K, Malley MF, DiMarco JD, Gougoutas JZ, Kadiyala P, Cheney DL, Tejwani RW, Murphy DK, Mcintyre KW, Yang X, Chao S, Leith L, Xiao Z, Mathur A, Chen BC, Wu DR, Traeger SC, McKinnon M, Barrish JC, Robl JA, Iwanowicz EJ, Suchard SJ, Dhar TG. Potin D, et al. Among authors: nicolai e. J Med Chem. 2006 Nov 30;49(24):6946-9. doi: 10.1021/jm0610806. J Med Chem. 2006. PMID: 17125246

3

Synthesis and SAR studies of novel triazolopyrimidine derivatives as potent, orally active angiotensin II receptor antagonists.

Nicolaï E, Curé G, Goyard J, Kirchner M, Teulon JM, Versigny A, Cazes M, Caussade F, Virone-Oddos A, Cloarec A. Nicolaï E, et al. J Med Chem. 1994 Jul 22;37(15):2371-86. doi: 10.1021/jm00041a016. J Med Chem. 1994. PMID: 8057285

4

Synthesis and structure-activity relationships of novel benzimidazole and imidazo[4,5-b]pyridine acid derivatives as thromboxane A2 receptor antagonists.

Nicolaï E, Goyard J, Benchetrit T, Teulon JM, Caussade F, Virone A, Delchambre C, Cloarec A. Nicolaï E, et al. J Med Chem. 1993 Apr 30;36(9):1175-87. doi: 10.1021/jm00061a008. J Med Chem. 1993. PMID: 8487256

5

G-protein-coupled receptor affinity prediction based on the use of a profiling dataset: QSAR design, synthesis, and experimental validation.

Rolland C, Gozalbes R, Nicolaï E, Paugam MF, Coussy L, Barbosa F, Horvath D, Revah F. Rolland C, et al. Among authors: nicolai e. J Med Chem. 2005 Oct 20;48(21):6563-74. doi: 10.1021/jm0500673. J Med Chem. 2005. PMID: 16220973

6

Synthesis and angiotensin II receptor antagonist activity of C-linked pyrazole derivatives.

Nicolaï E, Curé G, Goyard J, Kirchner M, Teulon JM, Versigny A, Cazes M, Virone-Oddos A, Caussade F, Cloarec A. Nicolaï E, et al. Chem Pharm Bull (Tokyo). 1994 Aug;42(8):1617-30. doi: 10.1248/cpb.42.1617. Chem Pharm Bull (Tokyo). 1994. PMID: 7954914

7

Design and optimization of a series of novel 2-cyano-pyrimidines as cathepsin K inhibitors.

Rankovic Z, Cai J, Kerr J, Fradera X, Robinson J, Mistry A, Hamilton E, McGarry G, Andrews F, Caulfield W, Cumming I, Dempster M, Waller J, Scullion P, Martin I, Mitchell A, Long C, Baugh M, Westwood P, Kinghorn E, Bruin J, Hamilton W, Uitdehaag J, van Zeeland M, Potin D, Saniere L, Fouquet A, Chevallier F, Deronzier H, Dorleans C, Nicolai E. Rankovic Z, et al. Among authors: nicolai e. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1524-7. doi: 10.1016/j.bmcl.2010.01.100. Epub 2010 Jan 25. Bioorg Med Chem Lett. 2010. PMID: 20149657

8

Optimisation of 2-cyano-pyrimidine inhibitors of cathepsin K: improving selectivity over hERG.

Rankovic Z, Cai J, Kerr J, Fradera X, Robinson J, Mistry A, Finlay W, McGarry G, Andrews F, Caulfield W, Cumming I, Dempster M, Waller J, Arbuckle W, Anderson M, Martin I, Mitchell A, Long C, Baugh M, Westwood P, Kinghorn E, Jones P, Uitdehaag JC, van Zeeland M, Potin D, Saniere L, Fouquet A, Chevallier F, Deronzier H, Dorleans C, Nicolai E. Rankovic Z, et al. Among authors: nicolai e. Bioorg Med Chem Lett. 2010 Nov 1;20(21):6237-41. doi: 10.1016/j.bmcl.2010.08.101. Epub 2010 Aug 24. Bioorg Med Chem Lett. 2010. PMID: 20843687

9

2-Phenyl-9H-purine-6-carbonitrile derivatives as selective cathepsin S inhibitors.

Cai J, Bennett DJ, Rankovic Z, Dempster M, Fradera X, Gillespie J, Cumming I, Finlay W, Baugh M, Boucharens S, Bruin J, Cameron KS, Hamilton W, Kerr J, Kinghorn E, McGarry G, Robinson J, Scullion P, Uitdehaag JC, van Zeeland M, Potin D, Saniere L, Fouquet A, Chevallier F, Deronzier H, Dorleans C, Nicolai E. Cai J, et al. Among authors: nicolai e. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4447-50. doi: 10.1016/j.bmcl.2010.06.049. Epub 2010 Jun 15. Bioorg Med Chem Lett. 2010. PMID: 20594841

10

Synthesis and multiparametric evaluation of thiadiazoles and oxadiazoles as diacylglycerol acyltransferase type 1 inhibitors.

Mougenot P, Namane C, Fett E, Goumy F, Dadji-Faïhun R, Langot G, Monseau C, Onofri B, Pacquet F, Pascal C, Crespin O, Ben-Hassine M, Ragot JL, Van-Pham T, Philippo C, Chatelain-Egger F, Péron P, Le Bail JC, Guillot E, Chamiot-Clerc P, Chabanaud MA, Pruniaux MP, Ménegotto J, Schmidt F, Venier O, Viviani F, Nicolai E. Mougenot P, et al. Among authors: nicolai e. Bioorg Med Chem Lett. 2016 Jan 1;26(1):25-32. doi: 10.1016/j.bmcl.2015.11.046. Epub 2015 Nov 25. Bioorg Med Chem Lett. 2016. PMID: 26627579

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