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Soluble markers for the assessment of biological activity with PTK787/ZK 222584 (PTK/ZK), a vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitor in patients with advanced colorectal cancer from two phase I trials.
Drevs J, Zirrgiebel U, Schmidt-Gersbach CI, Mross K, Medinger M, Lee L, Pinheiro J, Wood J, Thomas AL, Unger C, Henry A, Steward WP, Laurent D, Lebwohl D, Dugan M, Marmé D. Drevs J, et al. Among authors: marme d. Ann Oncol. 2005 Apr;16(4):558-65. doi: 10.1093/annonc/mdi118. Epub 2005 Feb 10. Ann Oncol. 2005. PMID: 15705616 Free article.
Dynamic contrast-enhanced magnetic resonance imaging as a biomarker for the pharmacological response of PTK787/ZK 222584, an inhibitor of the vascular endothelial growth factor receptor tyrosine kinases, in patients with advanced colorectal cancer and liver metastases: results from two phase I studies.
Morgan B, Thomas AL, Drevs J, Hennig J, Buchert M, Jivan A, Horsfield MA, Mross K, Ball HA, Lee L, Mietlowski W, Fuxuis S, Unger C, O'Byrne K, Henry A, Cherryman GR, Laurent D, Dugan M, Marmé D, Steward WP. Morgan B, et al. Among authors: marme d. J Clin Oncol. 2003 Nov 1;21(21):3955-64. doi: 10.1200/JCO.2003.08.092. Epub 2003 Sep 29. J Clin Oncol. 2003. PMID: 14517187 Clinical Trial.
PTK787/ZK 222584, a specific vascular endothelial growth factor-receptor tyrosine kinase inhibitor, affects the anatomy of the tumor vascular bed and the functional vascular properties as detected by dynamic enhanced magnetic resonance imaging.
Drevs J, Müller-Driver R, Wittig C, Fuxius S, Esser N, Hugenschmidt H, Konerding MA, Allegrini PR, Wood J, Hennig J, Unger C, Marmé D. Drevs J, et al. Among authors: marme d. Cancer Res. 2002 Jul 15;62(14):4015-22. Cancer Res. 2002. PMID: 12124335
Targeting of endothelial KDR receptors with 3G2 immunoliposomes in vitro.
Benzinger P, Martiny-Baron G, Reusch P, Siemeister G, Kley JT, Marmé D, Unger C, Massing U. Benzinger P, et al. Among authors: marme d. Biochim Biophys Acta. 2000 Jun 1;1466(1-2):71-8. doi: 10.1016/s0005-2736(00)00172-3. Biochim Biophys Acta. 2000. PMID: 10825432 Free article.
143 results