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Soluble markers for the assessment of biological activity with PTK787/ZK 222584 (PTK/ZK), a vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitor in patients with advanced colorectal cancer from two phase I trials.
Drevs J, Zirrgiebel U, Schmidt-Gersbach CI, Mross K, Medinger M, Lee L, Pinheiro J, Wood J, Thomas AL, Unger C, Henry A, Steward WP, Laurent D, Lebwohl D, Dugan M, Marmé D. Drevs J, et al. Among authors: pinheiro j. Ann Oncol. 2005 Apr;16(4):558-65. doi: 10.1093/annonc/mdi118. Epub 2005 Feb 10. Ann Oncol. 2005. PMID: 15705616 Free article.
Innovative approaches for designing and analyzing adaptive dose-ranging trials.
Bornkamp B, Bretz F, Dmitrienko A, Enas G, Gaydos B, Hsu CH, König F, Krams M, Liu Q, Neuenschwander B, Parke T, Pinheiro J, Roy A, Sax R, Shen F. Bornkamp B, et al. Among authors: pinheiro j. J Biopharm Stat. 2007;17(6):965-95. doi: 10.1080/10543400701643848. J Biopharm Stat. 2007. PMID: 18027208
Dose finding - a challenge in statistics.
Bretz F, Hsu J, Pinheiro J, Liu Y. Bretz F, et al. Among authors: pinheiro j. Biom J. 2008 Aug;50(4):480-504. doi: 10.1002/bimj.200810438. Biom J. 2008. PMID: 18663758 Review.
On a hybrid method in dose finding studies.
Bretz F, Pinheiro JC, Branson M. Bretz F, et al. Among authors: pinheiro jc. Methods Inf Med. 2004;43(5):457-60. Methods Inf Med. 2004. PMID: 15702200
742 results