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Type IX collagen knock-out mouse shows progressive hearing loss.
Suzuki N, Asamura K, Kikuchi Y, Takumi Y, Abe S, Imamura Y, Hayashi T, Aszodi A, Fässler R, Usami S. Suzuki N, et al. Among authors: fassler r. Neurosci Res. 2005 Mar;51(3):293-8. doi: 10.1016/j.neures.2004.12.001. Epub 2005 Jan 8. Neurosci Res. 2005. PMID: 15710493
Type IX collagen is crucial for normal hearing.
Asamura K, Abe S, Imamura Y, Aszodi A, Suzuki N, Hashimoto S, Takumi Y, Hayashi T, Fässler R, Nakamura Y, Usami S. Asamura K, et al. Among authors: fassler r. Neuroscience. 2005;132(2):493-500. doi: 10.1016/j.neuroscience.2005.01.013. Neuroscience. 2005. PMID: 15802199
Absence of the alpha1(IX) chain leads to a functional knock-out of the entire collagen IX protein in mice.
Hagg R, Hedbom E, Möllers U, Aszódi A, Fässler R, Bruckner P. Hagg R, et al. Among authors: fassler r. J Biol Chem. 1997 Aug 15;272(33):20650-4. doi: 10.1074/jbc.272.33.20650. J Biol Chem. 1997. PMID: 9252382 Free article.
The precise role of collagen IX in cartilage has been addressed previously by generating mice harboring an inactivated Col9a1 gene encoding the alpha1(IX) chain, i.e. one of the three constituent chains of collagen IX (Fassler, R., Schnegelsberg, P. N. J., Dausman, …
The precise role of collagen IX in cartilage has been addressed previously by generating mice harboring an inactivated Col9a1 gene encoding …
Role of collagen type II and perlecan in skeletal development.
Gustafsson E, Aszodi A, Ortega N, Hunziker EB, Denker HW, Werb Z, Fassler R. Gustafsson E, et al. Among authors: fassler r. Ann N Y Acad Sci. 2003 May;995:140-50. doi: 10.1111/j.1749-6632.2003.tb03217.x. Ann N Y Acad Sci. 2003. PMID: 12814946
410 results