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Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation.
Choudhury AR, Ju Z, Djojosubroto MW, Schienke A, Lechel A, Schaetzlein S, Jiang H, Stepczynska A, Wang C, Buer J, Lee HW, von Zglinicki T, Ganser A, Schirmacher P, Nakauchi H, Rudolph KL. Choudhury AR, et al. Among authors: buer j. Nat Genet. 2007 Jan;39(1):99-105. doi: 10.1038/ng1937. Epub 2006 Dec 3. Nat Genet. 2007. PMID: 17143283
Testing the importance of p27 degradation by the SCFskp2 pathway in murine models of lung and colon cancer.
Timmerbeul I, Garrett-Engele CM, Kossatz U, Chen X, Firpo E, Grünwald V, Kamino K, Wilkens L, Lehmann U, Buer J, Geffers R, Kubicka S, Manns MP, Porter PL, Roberts JM, Malek NP. Timmerbeul I, et al. Among authors: buer j. Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14009-14. doi: 10.1073/pnas.0606316103. Epub 2006 Sep 11. Proc Natl Acad Sci U S A. 2006. PMID: 16966613 Free PMC article.
Argyrin a reveals a critical role for the tumor suppressor protein p27(kip1) in mediating antitumor activities in response to proteasome inhibition.
Nickeleit I, Zender S, Sasse F, Geffers R, Brandes G, Sörensen I, Steinmetz H, Kubicka S, Carlomagno T, Menche D, Gütgemann I, Buer J, Gossler A, Manns MP, Kalesse M, Frank R, Malek NP. Nickeleit I, et al. Among authors: buer j. Cancer Cell. 2008 Jul 8;14(1):23-35. doi: 10.1016/j.ccr.2008.05.016. Cancer Cell. 2008. PMID: 18598941 Free article.
327 results