Lechel A - Search Results

1

The cellular level of telomere dysfunction determines induction of senescence or apoptosis in vivo.

Lechel A, Satyanarayana A, Ju Z, Plentz RR, Schaetzlein S, Rudolph C, Wilkens L, Wiemann SU, Saretzki G, Malek NP, Manns MP, Buer J, Rudolph KL. Lechel A, et al. EMBO Rep. 2005 Mar;6(3):275-81. doi: 10.1038/sj.embor.7400352. EMBO Rep. 2005. PMID: 15723042 Free PMC article.

2

Telomeres and telomerase: new targets for the treatment of liver cirrhosis and hepatocellular carcinoma.

Lechel A, Manns MP, Rudolph KL. Lechel A, et al. J Hepatol. 2004 Sep;41(3):491-7. doi: 10.1016/j.jhep.2004.06.010. J Hepatol. 2004. PMID: 15336455 Review. No abstract available.

3

Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation.

Choudhury AR, Ju Z, Djojosubroto MW, Schienke A, Lechel A, Schaetzlein S, Jiang H, Stepczynska A, Wang C, Buer J, Lee HW, von Zglinicki T, Ganser A, Schirmacher P, Nakauchi H, Rudolph KL. Choudhury AR, et al. Among authors: lechel a. Nat Genet. 2007 Jan;39(1):99-105. doi: 10.1038/ng1937. Epub 2006 Dec 3. Nat Genet. 2007. PMID: 17143283

4

Telomere shortening and inactivation of cell cycle checkpoints characterize human hepatocarcinogenesis.

Plentz RR, Park YN, Lechel A, Kim H, Nellessen F, Langkopf BH, Wilkens L, Destro A, Fiamengo B, Manns MP, Roncalli M, Rudolph KL. Plentz RR, et al. Among authors: lechel a. Hepatology. 2007 Apr;45(4):968-76. doi: 10.1002/hep.21552. Hepatology. 2007. PMID: 17393506

5

Telomerase deletion limits progression of p53-mutant hepatocellular carcinoma with short telomeres in chronic liver disease.

Lechel A, Holstege H, Begus Y, Schienke A, Kamino K, Lehmann U, Kubicka S, Schirmacher P, Jonkers J, Rudolph KL. Lechel A, et al. Gastroenterology. 2007 Apr;132(4):1465-75. doi: 10.1053/j.gastro.2007.01.045. Epub 2007 Jan 26. Gastroenterology. 2007. PMID: 17433324

6

Exonuclease-1 deletion impairs DNA damage signaling and prolongs lifespan of telomere-dysfunctional mice.

Schaetzlein S, Kodandaramireddy NR, Ju Z, Lechel A, Stepczynska A, Lilli DR, Clark AB, Rudolph C, Kuhnel F, Wei K, Schlegelberger B, Schirmacher P, Kunkel TA, Greenberg RA, Edelmann W, Rudolph KL. Schaetzlein S, et al. Among authors: lechel a. Cell. 2007 Sep 7;130(5):863-77. doi: 10.1016/j.cell.2007.08.029. Cell. 2007. PMID: 17803909 Free PMC article.

7

Rho GTPase and Wnt signaling pathways in hepatocarcinogenesis.

Lechel A, Rudolph KL. Lechel A, et al. Gastroenterology. 2008 Mar;134(3):875-8. doi: 10.1053/j.gastro.2008.01.055. Gastroenterology. 2008. PMID: 18325396 No abstract available.

8

p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice.

Begus-Nahrmann Y, Lechel A, Obenauf AC, Nalapareddy K, Peit E, Hoffmann E, Schlaudraff F, Liss B, Schirmacher P, Kestler H, Danenberg E, Barker N, Clevers H, Speicher MR, Rudolph KL. Begus-Nahrmann Y, et al. Among authors: lechel a. Nat Genet. 2009 Oct;41(10):1138-43. doi: 10.1038/ng.426. Epub 2009 Aug 30. Nat Genet. 2009. PMID: 19718028

9

CHK2-independent induction of telomere dysfunction checkpoints in stem and progenitor cells.

Nalapareddy K, Choudhury AR, Gompf A, Ju Z, Ravipati S, Leucht T, Lechel A, Rudolph KL. Nalapareddy K, et al. Among authors: lechel a. EMBO Rep. 2010 Aug;11(8):619-25. doi: 10.1038/embor.2010.83. Epub 2010 Jun 25. EMBO Rep. 2010. PMID: 20577265 Free PMC article.

10

Telomerase gene mutations are associated with cirrhosis formation.

Hartmann D, Srivastava U, Thaler M, Kleinhans KN, N'kontchou G, Scheffold A, Bauer K, Kratzer RF, Kloos N, Katz SF, Song Z, Begus-Nahrmann Y, Kleger A, von Figura G, Strnad P, Lechel A, Günes C, Potthoff A, Deterding K, Wedemeyer H, Ju Z, Song G, Xiao F, Gillen S, Schrezenmeier H, Mertens T, Ziol M, Friess H, Jarek M, Manns MP, Beaugrand M, Rudolph KL. Hartmann D, et al. Among authors: lechel a. Hepatology. 2011 May;53(5):1608-17. doi: 10.1002/hep.24217. Hepatology. 2011. PMID: 21520174

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