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Overexpression of neprilysin reduces alzheimer amyloid-beta42 (Abeta42)-induced neuron loss and intraneuronal Abeta42 deposits but causes a reduction in cAMP-responsive element-binding protein-mediated transcription, age-dependent axon pathology, and premature death in Drosophila.
Iijima-Ando K, Hearn SA, Granger L, Shenton C, Gatt A, Chiang HC, Hakker I, Zhong Y, Iijima K. Iijima-Ando K, et al. Among authors: iijima k. J Biol Chem. 2008 Jul 4;283(27):19066-76. doi: 10.1074/jbc.M710509200. Epub 2008 May 7. J Biol Chem. 2008. PMID: 18463098 Free PMC article.
1,965 results