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Evidence that human immunoglobulin M rheumatoid factors can Be derived from the natural autoantibody pool and undergo an antigen driven immune response in which somatically mutated rheumatoid factors have lower affinities for immunoglobulin G Fc than their germline counterparts.
Carayannopoulos MO, Potter KN, Li Y, Natvig JB, Capra JD. Carayannopoulos MO, et al. Among authors: capra jd. Scand J Immunol. 2000 Apr;51(4):327-36. doi: 10.1046/j.1365-3083.2000.00731.x. Scand J Immunol. 2000. PMID: 10736104 Free article.
325 results