Frei E - Search Results

1

Environmental pollutant and potent mutagen 3-nitrobenzanthrone forms DNA adducts after reduction by NAD(P)H:quinone oxidoreductase and conjugation by acetyltransferases and sulfotransferases in human hepatic cytosols.

Arlt VM, Stiborova M, Henderson CJ, Osborne MR, Bieler CA, Frei E, Martinek V, Sopko B, Wolf CR, Schmeiser HH, Phillips DH. Arlt VM, et al. Among authors: frei e. Cancer Res. 2005 Apr 1;65(7):2644-52. doi: 10.1158/0008-5472.CAN-04-3544. Cancer Res. 2005. PMID: 15805261

2

Role of P450 1A1 and P450 1A2 in bioactivation versus detoxication of the renal carcinogen aristolochic acid I: studies in Cyp1a1-/-, Cyp1a2-/-, and Cyp1a1/1a2-/- mice.

Arlt VM, Levová K, Bárta F, Shi Z, Evans JD, Frei E, Schmeiser HH, Nebert DW, Phillips DH, Stiborová M. Arlt VM, et al. Among authors: frei e. Chem Res Toxicol. 2011 Oct 17;24(10):1710-9. doi: 10.1021/tx200259y. Epub 2011 Sep 29. Chem Res Toxicol. 2011. PMID: 21932800

3

Effect of hepatic cytochrome P450 (P450) oxidoreductase deficiency on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-DNA adduct formation in P450 reductase conditional null mice.

Arlt VM, Singh R, Stiborová M, Gamboa da Costa G, Frei E, Evans JD, Farmer PB, Wolf CR, Henderson CJ, Phillips DH. Arlt VM, et al. Among authors: frei e. Drug Metab Dispos. 2011 Dec;39(12):2169-73. doi: 10.1124/dmd.111.041343. Epub 2011 Sep 22. Drug Metab Dispos. 2011. PMID: 21940903

4

The effect of aristolochic acid I on expression of NAD(P)H:quinone oxidoreductase in mice and rats--a comparative study.

Bárta F, Levová K, Frei E, Schmeiser HH, Arlt VM, Stiborová M. Bárta F, et al. Among authors: frei e. Mutat Res Genet Toxicol Environ Mutagen. 2014 Jul 1;768:1-7. doi: 10.1016/j.mrgentox.2014.01.012. Epub 2014 Apr 24. Mutat Res Genet Toxicol Environ Mutagen. 2014. PMID: 24769487 Free article.

5

Mechanisms of enzyme-catalyzed reduction of two carcinogenic nitro-aromatics, 3-nitrobenzanthrone and aristolochic acid I: Experimental and theoretical approaches.

Stiborová M, Frei E, Schmeiser HH, Arlt VM, Martínek V. Stiborová M, et al. Among authors: frei e. Int J Mol Sci. 2014 Jun 10;15(6):10271-95. doi: 10.3390/ijms150610271. Int J Mol Sci. 2014. PMID: 24918288 Free PMC article. Review.

6

Carcinogenic aristolochic acids upon activation by DT-diaphorase form adducts found in DNA of patients with Chinese herbs nephropathy.

Stiborová M, Frei E, Sopko B, Wiessler M, Schmeiser HH. Stiborová M, et al. Among authors: frei e. Carcinogenesis. 2002 Apr;23(4):617-25. doi: 10.1093/carcin/23.4.617. Carcinogenesis. 2002. PMID: 11960915

7

Sudan I is a potential carcinogen for humans: evidence for its metabolic activation and detoxication by human recombinant cytochrome P450 1A1 and liver microsomes.

Stiborová M, Martínek V, Rýdlová H, Hodek P, Frei E. Stiborová M, et al. Among authors: frei e. Cancer Res. 2002 Oct 15;62(20):5678-84. Cancer Res. 2002. PMID: 12384524

8

Human cytosolic enzymes involved in the metabolic activation of carcinogenic aristolochic acid: evidence for reductive activation by human NAD(P)H:quinone oxidoreductase.

Stiborová M, Frei E, Sopko B, Sopková K, Marková V, Lanková M, Kumstýrová T, Wiessler M, Schmeiser HH. Stiborová M, et al. Among authors: frei e. Carcinogenesis. 2003 Oct;24(10):1695-703. doi: 10.1093/carcin/bgg119. Epub 2003 Jul 17. Carcinogenesis. 2003. PMID: 12869422

9

Human hepatic and renal microsomes, cytochromes P450 1A1/2, NADPH:cytochrome P450 reductase and prostaglandin H synthase mediate the formation of aristolochic acid-DNA adducts found in patients with urothelial cancer.

Stiborová M, Frei E, Hodek P, Wiessler M, Schmeiser HH. Stiborová M, et al. Among authors: frei e. Int J Cancer. 2005 Jan 10;113(2):189-97. doi: 10.1002/ijc.20564. Int J Cancer. 2005. PMID: 15386410

10

Identification of a genotoxic mechanism for the carcinogenicity of the environmental pollutant and suspected human carcinogen o-anisidine.

Stiborová M, Miksanová M, Sulc M, Rýdlová H, Schmeiser HH, Frei E. Stiborová M, et al. Among authors: frei e. Int J Cancer. 2005 Sep 20;116(5):667-78. doi: 10.1002/ijc.21122. Int J Cancer. 2005. PMID: 15828049

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