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The thiazide-sensitive Na(+)-Cl(-) cotransporter gene, C1784T, and adrenergic receptor-beta3 gene, T727C, may be gene polymorphisms susceptible to the antihypertensive effect of thiazide diuretics.
Matayoshi T, Kamide K, Takiuchi S, Yoshii M, Miwa Y, Takami Y, Tanaka C, Banno M, Horio T, Nakamura S, Nakahama H, Yoshihara F, Inenaga T, Miyata T, Kawano Y. Matayoshi T, et al. Among authors: nakamura s. Hypertens Res. 2004 Nov;27(11):821-33. doi: 10.1291/hypres.27.821. Hypertens Res. 2004. PMID: 15824464 Free article.
Genetic polymorphisms of L-type calcium channel alpha1C and alpha1D subunit genes are associated with sensitivity to the antihypertensive effects of L-type dihydropyridine calcium-channel blockers.
Kamide K, Yang J, Matayoshi T, Takiuchi S, Horio T, Yoshii M, Miwa Y, Yasuda H, Yoshihara F, Nakamura S, Nakahama H, Miyata T, Kawano Y. Kamide K, et al. Among authors: nakamura s. Circ J. 2009 Apr;73(4):732-40. doi: 10.1253/circj.cj-08-0761. Epub 2009 Feb 17. Circ J. 2009. PMID: 19225208 Free article.
Association of intima-media thickening of carotid artery with genetic polymorphisms of the regulator of G-protein signaling 2 gene in patients with hypertension and in the general population.
Kamide K, Kokubo Y, Yang J, Takiuchi S, Horio T, Matsumoto S, Banno M, Matayoshi T, Yasuda H, Miwa Y, Yoshihara F, Nakamura S, Nakahama H, Iwashima Y, Oguro R, Ohishi M, Rakugi H, Okamura T, Miyata T, Kawano Y. Kamide K, et al. Among authors: nakamura s. Hypertens Res. 2011 Jun;34(6):740-6. doi: 10.1038/hr.2011.25. Epub 2011 Mar 31. Hypertens Res. 2011. PMID: 21451528
Genetic factors associated with elevation of uric acid after treatment with thiazide-like diuretic in patients with essential hypertension.
Ohta Y, Kamide K, Hanada H, Morimoto S, Nakahashi T, Takiuchi S, Ishimitsu T, Tsuchihashi T, Soma M, Tomohiro Katsuya T, Sugimoto K, Rakugi H, Oukura T, Higaki J, Matsuura H, Shinagawa T, Miwa Y, Sasaguri T, Igase M, Miki T, Takeda K, Higashiura K, Shimamoto K, Katabuchi R, Ueno M, Hosomi N, Kato J, Komai N, Kojima S, Sase K, Iwashima Y, Yoshihara F, Horio T, Nakamura S, Nakahama H, Miyata T, Kawano Y. Ohta Y, et al. Among authors: nakamura s. Hypertens Res. 2020 Mar;43(3):220-226. doi: 10.1038/s41440-019-0356-x. Epub 2019 Nov 20. Hypertens Res. 2020. PMID: 31748705 Clinical Trial.
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