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Glucose- and interleukin-1beta-induced beta-cell apoptosis requires Ca2+ influx and extracellular signal-regulated kinase (ERK) 1/2 activation and is prevented by a sulfonylurea receptor 1/inwardly rectifying K+ channel 6.2 (SUR/Kir6.2) selective potassium channel opener in human islets.
Maedler K, Størling J, Sturis J, Zuellig RA, Spinas GA, Arkhammar PO, Mandrup-Poulsen T, Donath MY. Maedler K, et al. Diabetes. 2004 Jul;53(7):1706-13. doi: 10.2337/diabetes.53.7.1706. Diabetes. 2004. PMID: 15220194
Type 1 database mellitus: an inflammatory disease of the islet.
Bergholdt R, Heding P, Nielsen K, Nolsøe R, Sparre T, Størling J, Nerup J, Pociot F, Mandrup-Poulsen T. Bergholdt R, et al. Adv Exp Med Biol. 2004;552:129-53. Adv Exp Med Biol. 2004. PMID: 15622962 Review. No abstract available.
308 results