Forrest AK - Search Results

1

Discovery and optimisation of potent, selective, ethanolamine inhibitors of bacterial phenylalanyl tRNA synthetase.

Jarvest RL, Erskine SG, Forrest AK, Fosberry AP, Hibbs MJ, Jones JJ, O'Hanlon PJ, Sheppard RJ, Worby A. Jarvest RL, et al. Among authors: forrest ak. Bioorg Med Chem Lett. 2005 May 2;15(9):2305-9. doi: 10.1016/j.bmcl.2005.03.003. Bioorg Med Chem Lett. 2005. PMID: 15837314

2

Nanomolar inhibitors of Staphylococcus aureus methionyl tRNA synthetase with potent antibacterial activity against gram-positive pathogens.

Jarvest RL, Berge JM, Berry V, Boyd HF, Brown MJ, Elder JS, Forrest AK, Fosberry AP, Gentry DR, Hibbs MJ, Jaworski DD, O'Hanlon PJ, Pope AJ, Rittenhouse S, Sheppard RJ, Slater-Radosti C, Worby A. Jarvest RL, et al. Among authors: forrest ak. J Med Chem. 2002 May 9;45(10):1959-62. doi: 10.1021/jm025502x. J Med Chem. 2002. PMID: 11985462

3

Optimisation of aryl substitution leading to potent methionyl tRNA synthetase inhibitors with excellent gram-positive antibacterial activity.

Jarvest RL, Berge JM, Brown MJ, Brown P, Elder JS, Forrest AK, Houge-Frydrych CS, O'Hanlon PJ, McNair DJ, Rittenhouse S, Sheppard RJ. Jarvest RL, et al. Among authors: forrest ak. Bioorg Med Chem Lett. 2003 Feb 24;13(4):665-8. doi: 10.1016/s0960-894x(02)01027-2. Bioorg Med Chem Lett. 2003. PMID: 12639554

4

Definition of the heterocyclic pharmacophore of bacterial methionyl tRNA synthetase inhibitors: potent antibacterially active non-quinolone analogues.

Jarvest RL, Armstrong SA, Berge JM, Brown P, Elder JS, Brown MJ, Copley RC, Forrest AK, Hamprecht DW, O'Hanlon PJ, Mitchell DJ, Rittenhouse S, Witty DR. Jarvest RL, et al. Among authors: forrest ak. Bioorg Med Chem Lett. 2004 Aug 2;14(15):3937-41. doi: 10.1016/j.bmcl.2004.05.070. Bioorg Med Chem Lett. 2004. PMID: 15225702

5

Aminoalkyl adenylate and aminoacyl sulfamate intermediate analogues differing greatly in affinity for their cognate Staphylococcus aureus aminoacyl tRNA synthetases.

Forrest AK, Jarvest RL, Mensah LM, O'Hanlon PJ, Pope AJ, Sheppard RJ. Forrest AK, et al. Bioorg Med Chem Lett. 2000 Aug 21;10(16):1871-4. doi: 10.1016/s0960-894x(00)00360-7. Bioorg Med Chem Lett. 2000. PMID: 10969988

6

Synthesis and activity of analogues of the isoleucyl tRNA synthetase inhibitor SB-203207.

Crasto CF, Forrest AK, Karoli T, March DR, Mensah L, O'Hanlon PJ, Nairn MR, Oldham MD, Yue W, Banwell MG, Easton CJ. Crasto CF, et al. Among authors: forrest ak. Bioorg Med Chem. 2003 Jul 3;11(13):2687-94. doi: 10.1016/s0968-0896(03)00237-2. Bioorg Med Chem. 2003. PMID: 12788342

7

Rational design of femtomolar inhibitors of isoleucyl tRNA synthetase from a binding model for pseudomonic acid-A.

Brown MJ, Mensah LM, Doyle ML, Broom NJ, Osbourne N, Forrest AK, Richardson CM, O'Hanlon PJ, Pope AJ. Brown MJ, et al. Among authors: forrest ak. Biochemistry. 2000 May 23;39(20):6003-11. doi: 10.1021/bi000148v. Biochemistry. 2000. PMID: 10821672

8

Analogues of SB-203207 as inhibitors of tRNA synthetases.

Banwell MG, Crasto CF, Easton CJ, Forrest AK, Karoli T, March DR, Mensah L, Nairn MR, O'Hanlon PJ, Oldham MD, Yue W. Banwell MG, et al. Among authors: forrest ak. Bioorg Med Chem Lett. 2000 Oct 16;10(20):2263-6. doi: 10.1016/s0960-894x(00)00456-x. Bioorg Med Chem Lett. 2000. PMID: 11055334

9

Chemistry of pseudomonic acid. Part 16. Aryl and heteroaryl ketone derivatives of monic acid.

Abson A, Broom NJ, Coates PA, Elder JS, Forrest AK, Hannan PC, Hicks AJ, O'Hanlon PJ, Masson ND, Pearson ND, Pons JE, Wilson JM. Abson A, et al. Among authors: forrest ak. J Antibiot (Tokyo). 1996 Apr;49(4):390-4. doi: 10.7164/antibiotics.49.390. J Antibiot (Tokyo). 1996. PMID: 8642004 Free article.

10

Synthesis and properties of macrolones characterized by two ether bonds in the linker.

Jakopović IP, Kragol G, Forrest AK, Frydrych CS, Stimac V, Kapić S, Skugor MM, Ilijas M, Paljetak HC, Jelić D, Holmes DJ, Hickey DM, Verbanac D, Eraković Haber V, Alihodzić S. Jakopović IP, et al. Among authors: forrest ak. Bioorg Med Chem. 2010 Sep 1;18(17):6578-88. doi: 10.1016/j.bmc.2010.07.007. Epub 2010 Jul 14. Bioorg Med Chem. 2010. PMID: 20688524

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