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Deficiency of MTH1 and/or OGG1 increases the accumulation of 8-oxoguanine in the brain of the AppNL-G-F/NL-G-F knock-in mouse model of Alzheimer's disease, accompanied by accelerated microgliosis and reduced anxiety-like behavior.
Mizuno Y, Abolhassani N, Mazzei G, Saito T, Saido TC, Yamasaki R, Kira JI, Nakabeppu Y. Mizuno Y, et al. Among authors: nakabeppu y. Neurosci Res. 2022 Apr;177:118-134. doi: 10.1016/j.neures.2021.11.009. Epub 2021 Nov 26. Neurosci Res. 2022. PMID: 34838904 Free article.
354 results