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Murine T-box transcription factor Tbx20 acts as a repressor during heart development, and is essential for adult heart integrity, function and adaptation.
Stennard FA, Costa MW, Lai D, Biben C, Furtado MB, Solloway MJ, McCulley DJ, Leimena C, Preis JI, Dunwoodie SL, Elliott DE, Prall OW, Black BL, Fatkin D, Harvey RP. Stennard FA, et al. Among authors: costa mw. Development. 2005 May;132(10):2451-62. doi: 10.1242/dev.01799. Epub 2005 Apr 20. Development. 2005. PMID: 15843414
Mutations in cardiac T-box factor gene TBX20 are associated with diverse cardiac pathologies, including defects of septation and valvulogenesis and cardiomyopathy.
Kirk EP, Sunde M, Costa MW, Rankin SA, Wolstein O, Castro ML, Butler TL, Hyun C, Guo G, Otway R, Mackay JP, Waddell LB, Cole AD, Hayward C, Keogh A, Macdonald P, Griffiths L, Fatkin D, Sholler GF, Zorn AM, Feneley MP, Winlaw DS, Harvey RP. Kirk EP, et al. Among authors: costa mw. Am J Hum Genet. 2007 Aug;81(2):280-91. doi: 10.1086/519530. Epub 2007 Jun 15. Am J Hum Genet. 2007. PMID: 17668378 Free PMC article.
Complex SUMO-1 regulation of cardiac transcription factor Nkx2-5.
Costa MW, Lee S, Furtado MB, Xin L, Sparrow DB, Martinez CG, Dunwoodie SL, Kurtenbach E, Mohun T, Rosenthal N, Harvey RP. Costa MW, et al. PLoS One. 2011;6(9):e24812. doi: 10.1371/journal.pone.0024812. Epub 2011 Sep 12. PLoS One. 2011. PMID: 21931855 Free PMC article.
Cardiogenic genes expressed in cardiac fibroblasts contribute to heart development and repair.
Furtado MB, Costa MW, Pranoto EA, Salimova E, Pinto AR, Lam NT, Park A, Snider P, Chandran A, Harvey RP, Boyd R, Conway SJ, Pearson J, Kaye DM, Rosenthal NA. Furtado MB, et al. Among authors: costa mw. Circ Res. 2014 Apr 25;114(9):1422-34. doi: 10.1161/CIRCRESAHA.114.302530. Epub 2014 Mar 20. Circ Res. 2014. PMID: 24650916 Free PMC article.
A novel conditional mouse model for Nkx2-5 reveals transcriptional regulation of cardiac ion channels.
Furtado MB, Wilmanns JC, Chandran A, Tonta M, Biben C, Eichenlaub M, Coleman HA, Berger S, Bouveret R, Singh R, Harvey RP, Ramialison M, Pearson JT, Parkington HC, Rosenthal NA, Costa MW. Furtado MB, et al. Among authors: costa mw. Differentiation. 2016 Jan-Mar;91(1-3):29-41. doi: 10.1016/j.diff.2015.12.003. Epub 2016 Feb 17. Differentiation. 2016. PMID: 26897459
Homeodomain factor Nkx2-5 in heart development and disease.
Harvey RP, Lai D, Elliott D, Biben C, Solloway M, Prall O, Stennard F, Schindeler A, Groves N, Lavulo L, Hyun C, Yeoh T, Costa M, Furtado M, Kirk E. Harvey RP, et al. Cold Spring Harb Symp Quant Biol. 2002;67:107-14. doi: 10.1101/sqb.2002.67.107. Cold Spring Harb Symp Quant Biol. 2002. PMID: 12858530 Review. No abstract available.
43 results