Okudaira N - Search Results

1

Lack of improvement of oral absorption of ME3277 by prodrug formation is ascribed to the intestinal efflux mediated by breast cancer resistant protein (BCRP/ABCG2).

Kondo C, Onuki R, Kusuhara H, Suzuki H, Suzuki M, Okudaira N, Kojima M, Ishiwata K, Jonker JW, Sugiyama Y. Kondo C, et al. Among authors: okudaira n. Pharm Res. 2005 Apr;22(4):613-8. doi: 10.1007/s11095-005-2487-9. Epub 2005 Apr 7. Pharm Res. 2005. PMID: 15846469

2

Effect of the fluoroquinolone antibacterial agent DX-619 on the apparent formation and renal clearances of 6β-hydroxycortisol, an endogenous probe for CYP3A4 inhibition, in healthy subjects.

Imamura Y, Murayama N, Okudaira N, Kurihara A, Inoue K, Yuasa H, Izumi T, Kusuhara H, Sugiyama Y. Imamura Y, et al. Among authors: okudaira n. Pharm Res. 2013 Feb;30(2):447-57. doi: 10.1007/s11095-012-0890-6. Epub 2012 Oct 17. Pharm Res. 2013. PMID: 23073666

3

Use of an isolated perfused kidney to assess renal clearance of drugs: information obtained in steady-state and non-steady-state experimental systems.

Okudaira N, Sugiyama Y. Okudaira N, et al. Pharm Biotechnol. 1996;8:211-38. doi: 10.1007/978-1-4899-1863-5_12. Pharm Biotechnol. 1996. PMID: 8791812 Review. No abstract available.

4

A study of the intestinal absorption of an ester-type prodrug, ME3229, in rats: active efflux transport as a cause of poor bioavailability of the active drug.

Okudaira N, Tatebayashi T, Speirs GC, Komiya I, Sugiyama Y. Okudaira N, et al. J Pharmacol Exp Ther. 2000 Aug;294(2):580-7. J Pharmacol Exp Ther. 2000. PMID: 10900235

5

Polarized efflux of mono- and diacid metabolites of ME3229, an ester-type prodrug of a glycoprotein IIb/IIIa receptor antagonist, in rat small intestine.

Okudaira N, Komiya I, Sugiyama Y. Okudaira N, et al. J Pharmacol Exp Ther. 2000 Nov;295(2):717-23. J Pharmacol Exp Ther. 2000. PMID: 11046110

6

6β-Hydroxycortisol is an endogenous probe for evaluation of drug-drug interactions involving a multispecific renal organic anion transporter, OAT3/SLC22A8, in healthy subjects.

Imamura Y, Tsuruya Y, Damme K, Heer D, Kumagai Y, Maeda K, Murayama N, Okudaira N, Kurihara A, Izumi T, Sugiyama Y, Kusuhara H. Imamura Y, et al. Among authors: okudaira n. Drug Metab Dispos. 2014 Apr;42(4):685-94. doi: 10.1124/dmd.113.055475. Epub 2014 Jan 31. Drug Metab Dispos. 2014. PMID: 24487120 Clinical Trial.

7

Up-regulation of carnitine transporters helps maintain tissue carnitine levels in carnitine deficiency induced by pivalic acid.

Okudaira N, Fujigaki M, Nakayoshi T, Komiya I, Sugiyama Y. Okudaira N, et al. Pharm Res. 2001 Apr;18(4):439-45. doi: 10.1023/a:1011042008169. Pharm Res. 2001. PMID: 11451029

8

Evaluation of the usefulness of breast cancer resistance protein (BCRP) knockout mice and BCRP inhibitor-treated monkeys to estimate the clinical impact of BCRP modulation on the pharmacokinetics of BCRP substrates.

Karibe T, Hagihara-Nakagomi R, Abe K, Imaoka T, Mikkaichi T, Yasuda S, Hirouchi M, Watanabe N, Okudaira N, Izumi T. Karibe T, et al. Among authors: okudaira n. Pharm Res. 2015 May;32(5):1634-47. doi: 10.1007/s11095-014-1563-4. Epub 2014 Nov 8. Pharm Res. 2015. PMID: 25380981

9

Prediction of fluoroquinolone-induced elevation in serum creatinine levels: a case of drug-endogenous substance interaction involving the inhibition of renal secretion.

Imamura Y, Murayama N, Okudaira N, Kurihara A, Okazaki O, Izumi T, Inoue K, Yuasa H, Kusuhara H, Sugiyama Y. Imamura Y, et al. Among authors: okudaira n. Clin Pharmacol Ther. 2011 Jan;89(1):81-8. doi: 10.1038/clpt.2010.232. Epub 2010 Dec 1. Clin Pharmacol Ther. 2011. PMID: 21124314 Clinical Trial.

10

Involvement of multiple transport systems in the disposition of an active metabolite of a prodrug-type new quinolone antibiotic, prulifloxacin.

Yagi Y, Shibutani S, Hodoshima N, Ishiwata K, Okudaira N, Li Q, Sai Y, Kato Y, Tsuji A. Yagi Y, et al. Among authors: okudaira n. Drug Metab Pharmacokinet. 2003;18(6):381-9. doi: 10.2133/dmpk.18.381. Drug Metab Pharmacokinet. 2003. PMID: 15618759 Free article.

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

87 results

Search Page

Filters