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Page 1
Modulation of P2X3 and P2X2/3 Receptors by Monoclonal Antibodies.
Shcherbatko A, Foletti D, Poulsen K, Strop P, Zhu G, Hasa-Moreno A, Melton Witt J, Loo C, Krimm S, Pios A, Yu J, Brown C, Lee JK, Stroud R, Rajpal A, Shelton D. Shcherbatko A, et al. Among authors: foletti d. J Biol Chem. 2016 Jun 3;291(23):12254-70. doi: 10.1074/jbc.M116.722330. Epub 2016 Apr 20. J Biol Chem. 2016. PMID: 27129281 Free PMC article.
Precise and efficient antibody epitope determination through library design, yeast display and next-generation sequencing.
Van Blarcom T, Rossi A, Foletti D, Sundar P, Pitts S, Bee C, Melton Witt J, Melton Z, Hasa-Moreno A, Shaughnessy L, Telman D, Zhao L, Cheung WL, Berka J, Zhai W, Strop P, Chaparro-Riggers J, Shelton DL, Pons J, Rajpal A. Van Blarcom T, et al. Among authors: foletti d. J Mol Biol. 2015 Mar 27;427(6 Pt B):1513-1534. doi: 10.1016/j.jmb.2014.09.020. Epub 2014 Oct 2. J Mol Biol. 2015. PMID: 25284753
Molecular Basis of Valine-Citrulline-PABC Linker Instability in Site-Specific ADCs and Its Mitigation by Linker Design.
Dorywalska M, Dushin R, Moine L, Farias SE, Zhou D, Navaratnam T, Lui V, Hasa-Moreno A, Casas MG, Tran TT, Delaria K, Liu SH, Foletti D, O'Donnell CJ, Pons J, Shelton DL, Rajpal A, Strop P. Dorywalska M, et al. Among authors: foletti d. Mol Cancer Ther. 2016 May;15(5):958-70. doi: 10.1158/1535-7163.MCT-15-1004. Epub 2016 Mar 4. Mol Cancer Ther. 2016. PMID: 26944918
Site-Dependent Degradation of a Non-Cleavable Auristatin-Based Linker-Payload in Rodent Plasma and Its Effect on ADC Efficacy.
Dorywalska M, Strop P, Melton-Witt JA, Hasa-Moreno A, Farias SE, Galindo Casas M, Delaria K, Lui V, Poulsen K, Sutton J, Bolton G, Zhou D, Moine L, Dushin R, Tran TT, Liu SH, Rickert M, Foletti D, Shelton DL, Pons J, Rajpal A. Dorywalska M, et al. Among authors: foletti d. PLoS One. 2015 Jul 10;10(7):e0132282. doi: 10.1371/journal.pone.0132282. eCollection 2015. PLoS One. 2015. PMID: 26161543 Free PMC article.
Improved Lysosomal Trafficking Can Modulate the Potency of Antibody Drug Conjugates.
DeVay RM, Delaria K, Zhu G, Holz C, Foletti D, Sutton J, Bolton G, Dushin R, Bee C, Pons J, Rajpal A, Liang H, Shelton D, Liu SH, Strop P. DeVay RM, et al. Among authors: foletti d. Bioconjug Chem. 2017 Apr 19;28(4):1102-1114. doi: 10.1021/acs.bioconjchem.7b00013. Epub 2017 Feb 13. Bioconjug Chem. 2017. PMID: 28151644
Effect of attachment site on stability of cleavable antibody drug conjugates.
Dorywalska M, Strop P, Melton-Witt JA, Hasa-Moreno A, Farias SE, Galindo Casas M, Delaria K, Lui V, Poulsen K, Loo C, Krimm S, Bolton G, Moine L, Dushin R, Tran TT, Liu SH, Rickert M, Foletti D, Shelton DL, Pons J, Rajpal A. Dorywalska M, et al. Among authors: foletti d. Bioconjug Chem. 2015 Apr 15;26(4):650-9. doi: 10.1021/bc5005747. Epub 2015 Feb 20. Bioconjug Chem. 2015. PMID: 25643134
Site-specific conjugation improves therapeutic index of antibody drug conjugates with high drug loading.
Strop P, Delaria K, Foletti D, Witt JM, Hasa-Moreno A, Poulsen K, Casas MG, Dorywalska M, Farias S, Pios A, Lui V, Dushin R, Zhou D, Navaratnam T, Tran TT, Sutton J, Lindquist KC, Han B, Liu SH, Shelton DL, Pons J, Rajpal A. Strop P, et al. Among authors: foletti d. Nat Biotechnol. 2015 Jul;33(7):694-6. doi: 10.1038/nbt.3274. Nat Biotechnol. 2015. PMID: 26154005 No abstract available.
32 results