Holt IJ - Search Results

1

Wobble modification deficiency in mutant tRNAs in patients with mitochondrial diseases.

Yasukawa T, Kirino Y, Ishii N, Holt IJ, Jacobs HT, Makifuchi T, Fukuhara N, Ohta S, Suzuki T, Watanabe K. Yasukawa T, et al. Among authors: holt ij. FEBS Lett. 2005 May 23;579(13):2948-52. doi: 10.1016/j.febslet.2005.04.038. FEBS Lett. 2005. PMID: 15893315 Free article.

2

Acquisition of the wobble modification in mitochondrial tRNALeu(CUN) bearing the G12300A mutation suppresses the MELAS molecular defect.

Kirino Y, Yasukawa T, Marjavaara SK, Jacobs HT, Holt IJ, Watanabe K, Suzuki T. Kirino Y, et al. Among authors: holt ij. Hum Mol Genet. 2006 Mar 15;15(6):897-904. doi: 10.1093/hmg/ddl007. Epub 2006 Jan 30. Hum Mol Genet. 2006. PMID: 16446307

3

The np 3243 MELAS mutation: damned if you aminoacylate, damned if you don't.

Jacobs HT, Holt IJ. Jacobs HT, et al. Among authors: holt ij. Hum Mol Genet. 2000 Mar 1;9(4):463-5. doi: 10.1093/hmg/9.4.463. Hum Mol Genet. 2000. PMID: 10699169 Review.

4

Response: The mitochondrial DNA replication bubble has not burst.

Holt IJ, Jacobs HT. Holt IJ, et al. Trends Biochem Sci. 2003 Jul;28(7):355-6. doi: 10.1016/S0968-0004(03)00133-6. Trends Biochem Sci. 2003. PMID: 12878001 No abstract available.

5

A bidirectional origin of replication maps to the major noncoding region of human mitochondrial DNA.

Yasukawa T, Yang MY, Jacobs HT, Holt IJ. Yasukawa T, et al. Among authors: holt ij. Mol Cell. 2005 Jun 10;18(6):651-62. doi: 10.1016/j.molcel.2005.05.002. Mol Cell. 2005. PMID: 15949440 Free article.

6

Systematic segregation to mutant mitochondrial DNA and accompanying loss of mitochondrial DNA in human NT2 teratocarcinoma Cybrids.

Turner CJ, Granycome C, Hurst R, Pohler E, Juhola MK, Juhola MI, Jacobs HT, Sutherland L, Holt IJ. Turner CJ, et al. Among authors: holt ij. Genetics. 2005 Aug;170(4):1879-85. doi: 10.1534/genetics.105.043653. Epub 2005 Jun 8. Genetics. 2005. PMID: 15944344 Free PMC article.

7

Replication of vertebrate mitochondrial DNA entails transient ribonucleotide incorporation throughout the lagging strand.

Yasukawa T, Reyes A, Cluett TJ, Yang MY, Bowmaker M, Jacobs HT, Holt IJ. Yasukawa T, et al. Among authors: holt ij. EMBO J. 2006 Nov 15;25(22):5358-71. doi: 10.1038/sj.emboj.7601392. Epub 2006 Oct 26. EMBO J. 2006. PMID: 17066082 Free PMC article.

8

The mitochondrial transcription termination factor mTERF modulates replication pausing in human mitochondrial DNA.

Hyvärinen AK, Pohjoismäki JL, Reyes A, Wanrooij S, Yasukawa T, Karhunen PJ, Spelbrink JN, Holt IJ, Jacobs HT. Hyvärinen AK, et al. Among authors: holt ij. Nucleic Acids Res. 2007;35(19):6458-74. doi: 10.1093/nar/gkm676. Epub 2007 Sep 20. Nucleic Acids Res. 2007. PMID: 17884915 Free PMC article.

9

Mitochondrial tRNALeu isoforms in lung carcinoma cybrid cells containing the np 3243 mtDNA mutation.

El Meziane A, Lehtinen SK, Holt IJ, Jacobs HT. El Meziane A, et al. Among authors: holt ij. Hum Mol Genet. 1998 Dec;7(13):2141-7. doi: 10.1093/hmg/7.13.2141. Hum Mol Genet. 1998. PMID: 9817933

10

Different cellular backgrounds confer a marked advantage to either mutant or wild-type mitochondrial genomes.

Dunbar DR, Moonie PA, Jacobs HT, Holt IJ. Dunbar DR, et al. Among authors: holt ij. Proc Natl Acad Sci U S A. 1995 Jul 3;92(14):6562-6. doi: 10.1073/pnas.92.14.6562. Proc Natl Acad Sci U S A. 1995. PMID: 7604033 Free PMC article.

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