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Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase.
Jankowsky JL, Fadale DJ, Anderson J, Xu GM, Gonzales V, Jenkins NA, Copeland NG, Lee MK, Younkin LH, Wagner SL, Younkin SG, Borchelt DR. Jankowsky JL, et al. Among authors: younkin lh, younkin sg. Hum Mol Genet. 2004 Jan 15;13(2):159-70. doi: 10.1093/hmg/ddh019. Epub 2003 Nov 25. Hum Mol Genet. 2004. PMID: 14645205
Dimeric amyloid beta protein rapidly accumulates in lipid rafts followed by apolipoprotein E and phosphorylated tau accumulation in the Tg2576 mouse model of Alzheimer's disease.
Kawarabayashi T, Shoji M, Younkin LH, Wen-Lang L, Dickson DW, Murakami T, Matsubara E, Abe K, Ashe KH, Younkin SG. Kawarabayashi T, et al. Among authors: younkin lh, younkin sg. J Neurosci. 2004 Apr 14;24(15):3801-9. doi: 10.1523/JNEUROSCI.5543-03.2004. J Neurosci. 2004. PMID: 15084661 Free PMC article.
75 results