Diederich F - Search Results

1

Quantification of cation-pi interactions in protein-ligand complexes: crystal-structure analysis of Factor Xa bound to a quaternary ammonium ion ligand.

Schärer K, Morgenthaler M, Paulini R, Obst-Sander U, Banner DW, Schlatter D, Benz J, Stihle M, Diederich F. Schärer K, et al. Among authors: diederich f. Angew Chem Int Ed Engl. 2005 Jul 11;44(28):4400-4. doi: 10.1002/anie.200500883. Angew Chem Int Ed Engl. 2005. PMID: 15952226 No abstract available.

2

A fluorine scan of thrombin inhibitors to map the fluorophilicity/fluorophobicity of an enzyme active site: evidence for C-F...C=O interactions.

Olsen JA, Banner DW, Seiler P, Obst Sander U, D'Arcy A, Stihle M, Müller K, Diederich F. Olsen JA, et al. Among authors: diederich f. Angew Chem Int Ed Engl. 2003 Jun 6;42(22):2507-11. doi: 10.1002/anie.200351268. Angew Chem Int Ed Engl. 2003. PMID: 12800172 No abstract available.

3

Orthogonal multipolar interactions in structural chemistry and biology.

Paulini R, Müller K, Diederich F. Paulini R, et al. Among authors: diederich f. Angew Chem Int Ed Engl. 2005 Mar 11;44(12):1788-805. doi: 10.1002/anie.200462213. Angew Chem Int Ed Engl. 2005. PMID: 15706577 Review.

4

Cation-pi interactions at the active site of factor Xa: dramatic enhancement upon stepwise N-alkylation of ammonium ions.

Salonen LM, Bucher C, Banner DW, Haap W, Mary JL, Benz J, Kuster O, Seiler P, Schweizer WB, Diederich F. Salonen LM, et al. Among authors: diederich f. Angew Chem Int Ed Engl. 2009;48(4):811-4. doi: 10.1002/anie.200804695. Angew Chem Int Ed Engl. 2009. PMID: 19101972 No abstract available.

5

Systematic investigation of halogen bonding in protein-ligand interactions.

Hardegger LA, Kuhn B, Spinnler B, Anselm L, Ecabert R, Stihle M, Gsell B, Thoma R, Diez J, Benz J, Plancher JM, Hartmann G, Banner DW, Haap W, Diederich F. Hardegger LA, et al. Among authors: diederich f. Angew Chem Int Ed Engl. 2011 Jan 3;50(1):314-8. doi: 10.1002/anie.201006781. Angew Chem Int Ed Engl. 2011. PMID: 21184410 No abstract available.

6

A fluorine scan of the phenylamidinium needle of tricyclic thrombin inhibitors: effects of fluorine substitution on pKa and binding affinity and evidence for intermolecular C-F...CN interactions.

Olsen J, Seiler P, Wagner B, Fischer H, Tschopp T, Obst-Sander U, Banner DW, Kansy M, Müller K, Diederich F. Olsen J, et al. Among authors: diederich f. Org Biomol Chem. 2004 May 7;2(9):1339-52. doi: 10.1039/b402515f. Epub 2004 Apr 14. Org Biomol Chem. 2004. PMID: 15105924

7

Fluorine interactions at the thrombin active site: protein backbone fragments H-C(alpha)-C=O comprise a favorable C-F environment and interactions of C-F with electrophiles.

Olsen JA, Banner DW, Seiler P, Wagner B, Tschopp T, Obst-Sander U, Kansy M, Müller K, Diederich F. Olsen JA, et al. Among authors: diederich f. Chembiochem. 2004 May 3;5(5):666-75. doi: 10.1002/cbic.200300907. Chembiochem. 2004. PMID: 15122639

8

Multipolar interactions in the D pocket of thrombin: large differences between tricyclic imide and lactam inhibitors.

Schweizer E, Hoffmann-Röder A, Olsen JA, Seiler P, Obst-Sander U, Wagner B, Kansy M, Banner DW, Diederich F. Schweizer E, et al. Among authors: diederich f. Org Biomol Chem. 2006 Jun 21;4(12):2364-75. doi: 10.1039/b602585d. Epub 2006 May 10. Org Biomol Chem. 2006. PMID: 16763681

9

Molecular recognition at the active site of catechol-o-methyltransferase: energetically favorable replacement of a water molecule imported by a bisubstrate inhibitor.

Ellermann M, Jakob-Roetne R, Lerner C, Borroni E, Schlatter D, Roth D, Ehler A, Rudolph MG, Diederich F. Ellermann M, et al. Among authors: diederich f. Angew Chem Int Ed Engl. 2009;48(48):9092-6. doi: 10.1002/anie.200904410. Angew Chem Int Ed Engl. 2009. PMID: 19882607 No abstract available.

10

Halogen bonding at the active sites of human cathepsin L and MEK1 kinase: efficient interactions in different environments.

Hardegger LA, Kuhn B, Spinnler B, Anselm L, Ecabert R, Stihle M, Gsell B, Thoma R, Diez J, Benz J, Plancher JM, Hartmann G, Isshiki Y, Morikami K, Shimma N, Haap W, Banner DW, Diederich F. Hardegger LA, et al. Among authors: diederich f. ChemMedChem. 2011 Nov 4;6(11):2048-54. doi: 10.1002/cmdc.201100353. Epub 2011 Sep 6. ChemMedChem. 2011. PMID: 21898833

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