Eckman CB - Search Results

1

Enzyme replacement therapy results in substantial improvements in early clinical phenotype in a mouse model of globoid cell leukodystrophy.

Lee WC, Courtenay A, Troendle FJ, Stallings-Mann ML, Dickey CA, DeLucia MW, Dickson DW, Eckman CB. Lee WC, et al. Among authors: eckman cb. FASEB J. 2005 Sep;19(11):1549-51. doi: 10.1096/fj.05-3826fje. Epub 2005 Jun 29. FASEB J. 2005. PMID: 15987783

2

Suppression of galactosylceramidase (GALC) expression in the twitcher mouse model of globoid cell leukodystrophy (GLD) is caused by nonsense-mediated mRNA decay (NMD).

Lee WC, Tsoi YK, Dickey CA, Delucia MW, Dickson DW, Eckman CB. Lee WC, et al. Among authors: eckman cb. Neurobiol Dis. 2006 Aug;23(2):273-80. doi: 10.1016/j.nbd.2006.03.005. Epub 2006 Jun 8. Neurobiol Dis. 2006. PMID: 16759875

3

Single-dose intracerebroventricular administration of galactocerebrosidase improves survival in a mouse model of globoid cell leukodystrophy.

Lee WC, Tsoi YK, Troendle FJ, DeLucia MW, Ahmed Z, Dicky CA, Dickson DW, Eckman CB. Lee WC, et al. Among authors: eckman cb. FASEB J. 2007 Aug;21(10):2520-7. doi: 10.1096/fj.06-6169com. Epub 2007 Apr 2. FASEB J. 2007. PMID: 17403939

4

HSP induction mediates selective clearance of tau phosphorylated at proline-directed Ser/Thr sites but not KXGS (MARK) sites.

Dickey CA, Dunmore J, Lu B, Wang JW, Lee WC, Kamal A, Burrows F, Eckman C, Hutton M, Petrucelli L. Dickey CA, et al. FASEB J. 2006 Apr;20(6):753-5. doi: 10.1096/fj.05-5343fje. Epub 2006 Feb 7. FASEB J. 2006. PMID: 16464956

5

Molecular characterization of mutations that cause globoid cell leukodystrophy and pharmacological rescue using small molecule chemical chaperones.

Lee WC, Kang D, Causevic E, Herdt AR, Eckman EA, Eckman CB. Lee WC, et al. Among authors: eckman ea, eckman cb. J Neurosci. 2010 Apr 21;30(16):5489-97. doi: 10.1523/JNEUROSCI.6383-09.2010. J Neurosci. 2010. PMID: 20410102 Free PMC article.

6

Deletion of the ubiquitin ligase CHIP leads to the accumulation, but not the aggregation, of both endogenous phospho- and caspase-3-cleaved tau species.

Dickey CA, Yue M, Lin WL, Dickson DW, Dunmore JH, Lee WC, Zehr C, West G, Cao S, Clark AM, Caldwell GA, Caldwell KA, Eckman C, Patterson C, Hutton M, Petrucelli L. Dickey CA, et al. J Neurosci. 2006 Jun 28;26(26):6985-96. doi: 10.1523/JNEUROSCI.0746-06.2006. J Neurosci. 2006. PMID: 16807328 Free PMC article.

7

Regulation of steady-state beta-amyloid levels in the brain by neprilysin and endothelin-converting enzyme but not angiotensin-converting enzyme.

Eckman EA, Adams SK, Troendle FJ, Stodola BA, Kahn MA, Fauq AH, Xiao HD, Bernstein KE, Eckman CB. Eckman EA, et al. Among authors: eckman cb. J Biol Chem. 2006 Oct 13;281(41):30471-8. doi: 10.1074/jbc.M605827200. Epub 2006 Aug 14. J Biol Chem. 2006. PMID: 16912050 Free article.

8

The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins.

Dickey CA, Kamal A, Lundgren K, Klosak N, Bailey RM, Dunmore J, Ash P, Shoraka S, Zlatkovic J, Eckman CB, Patterson C, Dickson DW, Nahman NS Jr, Hutton M, Burrows F, Petrucelli L. Dickey CA, et al. Among authors: eckman cb. J Clin Invest. 2007 Mar;117(3):648-58. doi: 10.1172/JCI29715. Epub 2007 Feb 15. J Clin Invest. 2007. PMID: 17304350 Free PMC article.

9

Altered expression of zonula occludens-2 precedes increased blood-brain barrier permeability in a murine model of fulminant hepatic failure.

Shimojima N, Eckman CB, McKinney M, Sevlever D, Yamamoto S, Lin W, Dickson DW, Nguyen JH. Shimojima N, et al. Among authors: eckman cb. J Invest Surg. 2008 May-Jun;21(3):101-8. doi: 10.1080/08941930802043565. J Invest Surg. 2008. PMID: 18569429 Free PMC article.

10

Reduction of Abeta accumulation in the Tg2576 animal model of Alzheimer's disease after oral administration of the phosphatidyl-inositol kinase inhibitor wortmannin.

Haugabook SJ, Le T, Yager D, Zenk B, Healy BM, Eckman EA, Prada C, Younkin L, Murphy P, Pinnix I, Onstead L, Sambamurti K, Golde TE, Dickson D, Younkin SG, Eckman CB. Haugabook SJ, et al. Among authors: eckman ea, eckman cb. FASEB J. 2001 Jan;15(1):16-18. doi: 10.1096/fj.00-0528fje. Epub 2000 Nov 9. FASEB J. 2001. PMID: 11099491

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