Graziano M - Search Results

1

Biaryl ureas as potent and orally efficacious melanin concentrating hormone receptor 1 antagonists for the treatment of obesity.

Palani A, Shapiro S, McBriar MD, Clader JW, Greenlee WJ, Spar B, Kowalski TJ, Farley C, Cook J, van Heek M, Weig B, O'neill K, Graziano M, Hawes B. Palani A, et al. Among authors: graziano m. J Med Chem. 2005 Jul 28;48(15):4746-9. doi: 10.1021/jm0503852. J Med Chem. 2005. PMID: 16033253

2

Tetrahydroisoquinolines as MCH-R1 antagonists.

Sasikumar TK, Qiang L, Wu WL, Burnett DA, Greenlee WJ, O'Neill K, Hawes BE, van Heek M, Graziano M. Sasikumar TK, et al. Among authors: graziano m. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4917-21. doi: 10.1016/j.bmcl.2006.06.055. Epub 2006 Jul 7. Bioorg Med Chem Lett. 2006. PMID: 16824753

3

Discovery of a novel, orally active himbacine-based thrombin receptor antagonist (SCH 530348) with potent antiplatelet activity.

Chackalamannil S, Wang Y, Greenlee WJ, Hu Z, Xia Y, Ahn HS, Boykow G, Hsieh Y, Palamanda J, Agans-Fantuzzi J, Kurowski S, Graziano M, Chintala M. Chackalamannil S, et al. Among authors: graziano m. J Med Chem. 2008 Jun 12;51(11):3061-4. doi: 10.1021/jm800180e. Epub 2008 May 1. J Med Chem. 2008. PMID: 18447380

4

The melanin-concentrating hormone receptor couples to multiple G proteins to activate diverse intracellular signaling pathways.

Hawes BE, Kil E, Green B, O'Neill K, Fried S, Graziano MP. Hawes BE, et al. Among authors: graziano mp. Endocrinology. 2000 Dec;141(12):4524-32. doi: 10.1210/endo.141.12.7833. Endocrinology. 2000. PMID: 11108264

5

In vivo responsiveness to ezetimibe correlates with niemann-pick C1 like-1 (NPC1L1) binding affinity: Comparison of multiple species NPC1L1 orthologs.

Hawes BE, O'neill KA, Yao X, Crona JH, Davis HR Jr, Graziano MP, Altmann SW. Hawes BE, et al. Mol Pharmacol. 2007 Jan;71(1):19-29. doi: 10.1124/mol.106.027896. Epub 2006 Sep 27. Mol Pharmacol. 2007. PMID: 17005902

6

Nociceptin activation of the human ORL1 receptor expressed in Chinese hamster ovary cells: functional homology with opioid receptors.

Fawzi AB, Zhang H, Weig B, Hawes B, Graziano MP. Fawzi AB, et al. Among authors: graziano mp. Eur J Pharmacol. 1997 Oct 8;336(2-3):233-42. doi: 10.1016/s0014-2999(97)01227-2. Eur J Pharmacol. 1997. PMID: 9384238

7

Purification of milligram quantities of human leptin from recombinant E. coli.

Fawzi AB, Zhang H, van Heek M, Graziano MP. Fawzi AB, et al. Among authors: graziano mp. Horm Metab Res. 1996 Dec;28(12):694-7. doi: 10.1055/s-2007-979880. Horm Metab Res. 1996. PMID: 9013744

8

Nociceptin (ORL-1) and mu-opioid receptors mediate mitogen-activated protein kinase activation in CHO cells through a Gi-coupled signaling pathway: evidence for distinct mechanisms of agonist-mediated desensitization.

Hawes BE, Fried S, Yao X, Weig B, Graziano MP. Hawes BE, et al. Among authors: graziano mp. J Neurochem. 1998 Sep;71(3):1024-33. doi: 10.1046/j.1471-4159.1998.71031024.x. J Neurochem. 1998. PMID: 9721727 Free article.

9

Diet-induced obese mice develop peripheral, but not central, resistance to leptin.

Van Heek M, Compton DS, France CF, Tedesco RP, Fawzi AB, Graziano MP, Sybertz EJ, Strader CD, Davis HR Jr. Van Heek M, et al. Among authors: graziano mp. J Clin Invest. 1997 Feb 1;99(3):385-90. doi: 10.1172/JCI119171. J Clin Invest. 1997. PMID: 9022070 Free PMC article. Clinical Trial.

10

Effect of chronic central administration of glucagon-like peptide-1 (7-36) amide on food consumption and body weight in normal and obese rats.

Davis HR Jr, Mullins DE, Pines JM, Hoos LM, France CF, Compton DS, Graziano MP, Sybertz EJ, Strader CD, Van Heek M. Davis HR Jr, et al. Among authors: graziano mp. Obes Res. 1998 Mar;6(2):147-56. doi: 10.1002/j.1550-8528.1998.tb00329.x. Obes Res. 1998. PMID: 9545022 Free article.

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