Castedo L - Search Results

1

Structure-based design, synthesis, and biological evaluation of inhibitors of Mycobacterium tuberculosis type II dehydroquinase.

Sánchez-Sixto C, Prazeres VF, Castedo L, Lamb H, Hawkins AR, González-Bello C. Sánchez-Sixto C, et al. Among authors: castedo l. J Med Chem. 2005 Jul 28;48(15):4871-81. doi: 10.1021/jm0501836. J Med Chem. 2005. PMID: 16033267

2

Synthesis of 3-alkyl enol mimics inhibitors of type II dehydroquinase: factors influencing their inhibition potency.

Blanco B, Sedes A, Peón A, Lamb H, Hawkins AR, Castedo L, González-Bello C. Blanco B, et al. Among authors: castedo l. Org Biomol Chem. 2012 May 14;10(18):3662-76. doi: 10.1039/c2ob07081b. Epub 2012 Mar 26. Org Biomol Chem. 2012. PMID: 22447158

3

Parallel solid-phase synthesis and evaluation of inhibitors of Streptomyces coelicolor type II dehydroquinase.

González-Bello C, Lence E, Toscano MD, Castedo L, Coggins JR, Abell C. González-Bello C, et al. Among authors: castedo l. J Med Chem. 2003 Dec 18;46(26):5735-44. doi: 10.1021/jm030987q. J Med Chem. 2003. PMID: 14667226

4

Determination of the bound conformation of a competitive nanomolar inhibitor of mycobacterium tuberculosis type II dehydroquinase by NMR spectroscopy.

Prazeres VF, Sánchez-Sixto C, Castedo L, Canales A, Cañada FJ, Jiménez-Barbero J, Lamb H, Hawkins AR, González-Bello C. Prazeres VF, et al. Among authors: castedo l. ChemMedChem. 2006 Sep;1(9):990-6. doi: 10.1002/cmdc.200600100. ChemMedChem. 2006. PMID: 16952136

5

Progress in type II dehydroquinase inhibitors: from concept to practice.

González-Bello C, Castedo L. González-Bello C, et al. Among authors: castedo l. Med Res Rev. 2007 Mar;27(2):177-208. doi: 10.1002/med.20076. Med Res Rev. 2007. PMID: 17004270 Review.

6

Nanomolar competitive inhibitors of Mycobacterium tuberculosis and Streptomyces coelicolor type II dehydroquinase.

Prazeres VF, Sánchez-Sixto C, Castedo L, Lamb H, Hawkins AR, Riboldi-Tunnicliffe A, Coggins JR, Lapthorn AJ, González-Bello C. Prazeres VF, et al. Among authors: castedo l. ChemMedChem. 2007 Feb;2(2):194-207. doi: 10.1002/cmdc.200600208. ChemMedChem. 2007. PMID: 17245805

7

Competitive inhibitors of Helicobacter pylori type II dehydroquinase: synthesis, biological evaluation, and NMR studies.

Sánchez-Sixto C, Prazeres VF, Castedo L, Suh SW, Lamb H, Hawkins AR, Cañada FJ, Jiménez-Barbero J, González-Bello C. Sánchez-Sixto C, et al. Among authors: castedo l. ChemMedChem. 2008 May;3(5):756-70. doi: 10.1002/cmdc.200700307. ChemMedChem. 2008. PMID: 18200648

8

2-substituted-3-dehydroquinic acids as potent competitive inhibitors of type II dehydroquinase.

Prazeres VF, Castedo L, Lamb H, Hawkins AR, González-Bello C. Prazeres VF, et al. Among authors: castedo l. ChemMedChem. 2009 Dec;4(12):1980-4. doi: 10.1002/cmdc.200900319. ChemMedChem. 2009. PMID: 19856378 No abstract available.

9

Synthesis and biological evaluation of new nanomolar competitive inhibitors of Helicobacter pylori type II dehydroquinase. Structural details of the role of the aromatic moieties with essential residues.

Prazeres VF, Tizón L, Otero JM, Guardado-Calvo P, Llamas-Saiz AL, van Raaij MJ, Castedo L, Lamb H, Hawkins AR, González-Bello C. Prazeres VF, et al. Among authors: castedo l. J Med Chem. 2010 Jan 14;53(1):191-200. doi: 10.1021/jm9010466. J Med Chem. 2010. PMID: 19911771

10

Understanding the key factors that control the inhibition of type II dehydroquinase by (2R)-2-benzyl-3-dehydroquinic acids.

Peón A, Otero JM, Tizón L, Prazeres VF, Llamas-Saiz AL, Fox GC, van Raaij MJ, Lamb H, Hawkins AR, Gago F, Castedo L, González-Bello C. Peón A, et al. Among authors: castedo l. ChemMedChem. 2010 Oct 4;5(10):1726-33. doi: 10.1002/cmdc.201000281. ChemMedChem. 2010. PMID: 20815012

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