The ancient drug salicylate directly activates AMP-activated protein kinase.
Hawley SA, Fullerton MD, Ross FA, Schertzer JD, Chevtzoff C, Walker KJ, Peggie MW, Zibrova D, Green KA, Mustard KJ, Kemp BE, Sakamoto K, Steinberg GR, Hardie DG.
Hawley SA, et al. Among authors: mustard kj.
Science. 2012 May 18;336(6083):918-22. doi: 10.1126/science.1215327. Epub 2012 Apr 19.
Science. 2012.
PMID: 22517326
Free PMC article.