Leder P - Search Results

1

A bifunctional targeted peptide that blocks HER-2 tyrosine kinase and disables mitochondrial function in HER-2-positive carcinoma cells.

Fantin VR, Berardi MJ, Babbe H, Michelman MV, Manning CM, Leder P. Fantin VR, et al. Among authors: leder p. Cancer Res. 2005 Aug 1;65(15):6891-900. doi: 10.1158/0008-5472.CAN-05-0395. Cancer Res. 2005. PMID: 16061673

2

A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth.

Fantin VR, Berardi MJ, Scorrano L, Korsmeyer SJ, Leder P. Fantin VR, et al. Among authors: leder p. Cancer Cell. 2002 Jul;2(1):29-42. doi: 10.1016/s1535-6108(02)00082-x. Cancer Cell. 2002. PMID: 12150823 Free article.

3

F16, a mitochondriotoxic compound, triggers apoptosis or necrosis depending on the genetic background of the target carcinoma cell.

Fantin VR, Leder P. Fantin VR, et al. Among authors: leder p. Cancer Res. 2004 Jan 1;64(1):329-36. doi: 10.1158/0008-5472.can-03-0899. Cancer Res. 2004. PMID: 14729642

4

Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance.

Fantin VR, St-Pierre J, Leder P. Fantin VR, et al. Among authors: leder p. Cancer Cell. 2006 Jun;9(6):425-34. doi: 10.1016/j.ccr.2006.04.023. Cancer Cell. 2006. PMID: 16766262 Free article.

5

Mitochondriotoxic compounds for cancer therapy.

Fantin VR, Leder P. Fantin VR, et al. Among authors: leder p. Oncogene. 2006 Aug 7;25(34):4787-97. doi: 10.1038/sj.onc.1209599. Oncogene. 2006. PMID: 16892091 Review.

6

Mutation of the murine Bloom's syndrome gene produces global genome destabilization.

Chester N, Babbe H, Pinkas J, Manning C, Leder P. Chester N, et al. Among authors: leder p. Mol Cell Biol. 2006 Sep;26(17):6713-26. doi: 10.1128/MCB.00296-06. Mol Cell Biol. 2006. PMID: 16914751 Free PMC article.

7

Genomic instability resulting from Blm deficiency compromises development, maintenance, and function of the B cell lineage.

Babbe H, McMenamin J, Hobeika E, Wang J, Rodig SJ, Reth M, Leder P. Babbe H, et al. Among authors: leder p. J Immunol. 2009 Jan 1;182(1):347-60. doi: 10.4049/jimmunol.182.1.347. J Immunol. 2009. PMID: 19109166 Free PMC article.

8

A cytoskeleton-based functional genetic screen identifies Bcl-xL as an enhancer of metastasis, but not primary tumor growth.

Martin SS, Ridgeway AG, Pinkas J, Lu Y, Reginato MJ, Koh EY, Michelman M, Daley GQ, Brugge JS, Leder P. Martin SS, et al. Among authors: leder p. Oncogene. 2004 Jun 3;23(26):4641-5. doi: 10.1038/sj.onc.1207595. Oncogene. 2004. PMID: 15064711

9

The extracellular region of heregulin is sufficient to promote mammary gland proliferation and tumorigenesis but not apoptosis.

Weinstein EJ, Leder P. Weinstein EJ, et al. Among authors: leder p. Cancer Res. 2000 Jul 15;60(14):3856-61. Cancer Res. 2000. PMID: 10919660

10

The Bloom's syndrome helicase is critical for development and function of the alphabeta T-cell lineage.

Babbe H, Chester N, Leder P, Reizis B. Babbe H, et al. Among authors: leder p. Mol Cell Biol. 2007 Mar;27(5):1947-59. doi: 10.1128/MCB.01402-06. Epub 2007 Jan 8. Mol Cell Biol. 2007. PMID: 17210642 Free PMC article.

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