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De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma.
Shi DD, Savani MR, Levitt MM, Wang AC, Endress JE, Bird CE, Buehler J, Stopka SA, Regan MS, Lin YF, Puliyappadamba VT, Gao W, Khanal J, Evans L, Lee JH, Guo L, Xiao Y, Xu M, Huang B, Jennings RB, Bonal DM, Martin-Sandoval MS, Dang T, Gattie LC, Cameron AB, Lee S, Asara JM, Kornblum HI, Mak TW, Looper RE, Nguyen QD, Signoretti S, Gradl S, Sutter A, Jeffers M, Janzer A, Lehrman MA, Zacharias LG, Mathews TP, Losman JA, Richardson TE, Cahill DP, DeBerardinis RJ, Ligon KL, Xu L, Ly P, Agar NYR, Abdullah KG, Harris IS, Kaelin WG Jr, McBrayer SK. Shi DD, et al. Among authors: lee jh, lee s. Cancer Cell. 2022 Sep 12;40(9):939-956.e16. doi: 10.1016/j.ccell.2022.07.011. Epub 2022 Aug 18. Cancer Cell. 2022. PMID: 35985343 Free PMC article.
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation.
Koivunen P, Lee S, Duncan CG, Lopez G, Lu G, Ramkissoon S, Losman JA, Joensuu P, Bergmann U, Gross S, Travins J, Weiss S, Looper R, Ligon KL, Verhaak RG, Yan H, Kaelin WG Jr. Koivunen P, et al. Among authors: lee s. Nature. 2012 Feb 15;483(7390):484-8. doi: 10.1038/nature10898. Nature. 2012. PMID: 22343896 Free PMC article.
Drug Development.
Sadhu C, Liu W, Kundu J, Thompson J, Emery M, Epling D, Smith B, Shah I, Paranjpe M, Lee S, Fang CL, Walsh A, Placidi M, Mathur K, Mondick J, Chapel S, Ghetti B, Carter T, Paul SM, Yao J, Sah DWY. Sadhu C, et al. Among authors: lee s. Alzheimers Dement. 2024 Dec;20 Suppl 6:e091630. doi: 10.1002/alz.091630. Alzheimers Dement. 2024. PMID: 39782482
Drug Development.
Lee SK. Lee SK. Alzheimers Dement. 2024 Dec;20 Suppl 6:e091984. doi: 10.1002/alz.091984. Alzheimers Dement. 2024. PMID: 39782446
Dementia Care Practice.
van der Schaar J, van der Lee SJ, Asscher E, van der Flier WM, Pijnenburg YAL, Bredenoord AL, van den Hoven MA, Smets EMA, Visser LNC. van der Schaar J, et al. Among authors: van der lee sj. Alzheimers Dement. 2024 Dec;20 Suppl 5:e091187. doi: 10.1002/alz.091187. Alzheimers Dement. 2024. PMID: 39781810
133,002 results
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