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Sustained serine proteases activity by prolonged increase in pH leads to degradation of lipid processing enzymes and profound alterations of barrier function and stratum corneum integrity.
Hachem JP, Man MQ, Crumrine D, Uchida Y, Brown BE, Rogiers V, Roseeuw D, Feingold KR, Elias PM. Hachem JP, et al. Among authors: crumrine d. J Invest Dermatol. 2005 Sep;125(3):510-20. doi: 10.1111/j.0022-202X.2005.23838.x. J Invest Dermatol. 2005. PMID: 16117792 Free article.
Basis for the permeability barrier abnormality in lamellar ichthyosis.
Elias PM, Schmuth M, Uchida Y, Rice RH, Behne M, Crumrine D, Feingold KR, Holleran WM, Pharm D. Elias PM, et al. Among authors: crumrine d. Exp Dermatol. 2002 Jun;11(3):248-56. doi: 10.1034/j.1600-0625.2001.110308.x. Exp Dermatol. 2002. PMID: 12102664
Short-term glucocorticoid treatment compromises both permeability barrier homeostasis and stratum corneum integrity: inhibition of epidermal lipid synthesis accounts for functional abnormalities.
Kao JS, Fluhr JW, Man MQ, Fowler AJ, Hachem JP, Crumrine D, Ahn SK, Brown BE, Elias PM, Feingold KR. Kao JS, et al. Among authors: crumrine d. J Invest Dermatol. 2003 Mar;120(3):456-64. doi: 10.1046/j.1523-1747.2003.12053.x. J Invest Dermatol. 2003. PMID: 12603860 Free article.
143 results