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Modifying the protease, antiprotease pattern by elafin overexpression protects mice from colitis.
Motta JP, Magne L, Descamps D, Rolland C, Squarzoni-Dale C, Rousset P, Martin L, Cenac N, Balloy V, Huerre M, Fröhlich LF, Jenne D, Wartelle J, Belaaouaj A, Mas E, Vinel JP, Alric L, Chignard M, Vergnolle N, Sallenave JM. Motta JP, et al. Among authors: huerre m. Gastroenterology. 2011 Apr;140(4):1272-82. doi: 10.1053/j.gastro.2010.12.050. Epub 2011 Jan 1. Gastroenterology. 2011. PMID: 21199654
Neutrophil elastase degrades cystic fibrosis transmembrane conductance regulator via calpains and disables channel function in vitro and in vivo.
Le Gars M, Descamps D, Roussel D, Saussereau E, Guillot L, Ruffin M, Tabary O, Hong SS, Boulanger P, Paulais M, Malleret L, Belaaouaj A, Edelman A, Huerre M, Chignard M, Sallenave JM. Le Gars M, et al. Among authors: huerre m. Am J Respir Crit Care Med. 2013 Jan 15;187(2):170-9. doi: 10.1164/rccm.201205-0875OC. Epub 2012 Dec 6. Am J Respir Crit Care Med. 2013. PMID: 23220915
241 results