Nakagawa H - Search Results

1

Pharmacogenomics of the human ABC transporter ABCG2: from functional evaluation to drug molecular design.

Ishikawa T, Tamura A, Saito H, Wakabayashi K, Nakagawa H. Ishikawa T, et al. Among authors: nakagawa h. Naturwissenschaften. 2005 Oct;92(10):451-63. doi: 10.1007/s00114-005-0019-4. Naturwissenschaften. 2005. PMID: 16160819 Review.

2

Synthesis and evaluation of 3D templates based on a taxane skeleton to circumvent P-glycoprotein-associated multidrug resistance of cancer.

Takahashi T, Nakai K, Doi T, Yasunaga M, Nakagawa H, Ishikawa T. Takahashi T, et al. Among authors: nakagawa h. Bioorg Med Chem Lett. 2005 May 16;15(10):2601-5. doi: 10.1016/j.bmcl.2005.03.038. Bioorg Med Chem Lett. 2005. PMID: 15863325

3

Molecular modeling of new camptothecin analogues to circumvent ABCG2-mediated drug resistance in cancer.

Nakagawa H, Saito H, Ikegami Y, Aida-Hyugaji S, Sawada S, Ishikawa T. Nakagawa H, et al. Cancer Lett. 2006 Mar 8;234(1):81-9. doi: 10.1016/j.canlet.2005.05.052. Epub 2005 Nov 23. Cancer Lett. 2006. PMID: 16309825 Review.

4

Transport mechanism-based drug molecular design: novel camptothecin analogues to circumvent ABCG2-associated drug resistance of human tumor cells.

Ishikawa T, Ikegami Y, Sano K, Nakagawa H, Sawada S. Ishikawa T, et al. Among authors: nakagawa h. Curr Pharm Des. 2006;12(3):313-25. doi: 10.2174/138161206775201992. Curr Pharm Des. 2006. PMID: 16454746 Review.

5

A new strategy of high-speed screening and quantitative structure-activity relationship analysis to evaluate human ATP-binding cassette transporter ABCG2-drug interactions.

Saito H, Hirano H, Nakagawa H, Fukami T, Oosumi K, Murakami K, Kimura H, Kouchi T, Konomi M, Tao E, Tsujikawa N, Tarui S, Nagakura M, Osumi M, Ishikawa T. Saito H, et al. Among authors: nakagawa h. J Pharmacol Exp Ther. 2006 Jun;317(3):1114-24. doi: 10.1124/jpet.105.099036. Epub 2006 Feb 17. J Pharmacol Exp Ther. 2006. PMID: 16489126

6

Identification of cysteine residues critically involved in homodimer formation and protein expression of human ATP-binding cassette transporter ABCG2: a new approach using the flp recombinase system.

Wakabayashi K, Nakagawa H, Adachi T, Kii I, Kobatake E, Kudo A, Ishikawa T. Wakabayashi K, et al. Among authors: nakagawa h. J Exp Ther Oncol. 2006;5(3):205-22. J Exp Ther Oncol. 2006. PMID: 16528971

7

Functional validation of the genetic polymorphisms of human ATP-binding cassette (ABC) transporter ABCG2: identification of alleles that are defective in porphyrin transport.

Tamura A, Watanabe M, Saito H, Nakagawa H, Kamachi T, Okura I, Ishikawa T. Tamura A, et al. Among authors: nakagawa h. Mol Pharmacol. 2006 Jul;70(1):287-96. doi: 10.1124/mol.106.023556. Epub 2006 Apr 11. Mol Pharmacol. 2006. PMID: 16608919

8

High-speed screening and QSAR analysis of human ATP-binding cassette transporter ABCB11 (bile salt export pump) to predict drug-induced intrahepatic cholestasis.

Hirano H, Kurata A, Onishi Y, Sakurai A, Saito H, Nakagawa H, Nagakura M, Tarui S, Kanamori Y, Kitajima M, Ishikawa T. Hirano H, et al. Among authors: nakagawa h. Mol Pharm. 2006 May-Jun;3(3):252-65. doi: 10.1021/mp060004w. Mol Pharm. 2006. PMID: 16749857

9

Identification of two biologically crucial hydroxyl groups of (-)-epigallocatechin gallate in osteoclast culture.

Nakagawa H, Hasumi K, Takami M, Aida-Hyugaji S, Woo JT, Nagai K, Ishikawa T, Wachi M. Nakagawa H, et al. Biochem Pharmacol. 2007 Jan 1;73(1):34-43. doi: 10.1016/j.bcp.2006.09.002. Epub 2006 Sep 12. Biochem Pharmacol. 2007. PMID: 17034764

10

Evaluation of human P-glycoprotein (MDR1/ABCB1) ATPase activity assay method by comparing with in vitro transport measurements: Michaelis-Menten kinetic analysis to estimate the affinity of P-glycoprotein to drugs.

Shirasaka Y, Onishi Y, Sakurai A, Nakagawa H, Ishikawa T, Yamashita S. Shirasaka Y, et al. Among authors: nakagawa h. Biol Pharm Bull. 2006 Dec;29(12):2465-71. doi: 10.1248/bpb.29.2465. Biol Pharm Bull. 2006. PMID: 17142983 Free article.

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