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Page 1
Expression of Mfn2, the Charcot-Marie-Tooth neuropathy type 2A gene, in human skeletal muscle: effects of type 2 diabetes, obesity, weight loss, and the regulatory role of tumor necrosis factor alpha and interleukin-6.
Bach D, Naon D, Pich S, Soriano FX, Vega N, Rieusset J, Laville M, Guillet C, Boirie Y, Wallberg-Henriksson H, Manco M, Calvani M, Castagneto M, Palacín M, Mingrone G, Zierath JR, Vidal H, Zorzano A. Bach D, et al. Among authors: naon d. Diabetes. 2005 Sep;54(9):2685-93. doi: 10.2337/diabetes.54.9.2685. Diabetes. 2005. PMID: 16123358
Genes involved in mitochondrial biogenesis/function are induced in response to bilio-pancreatic diversion in morbidly obese individuals with normal glucose tolerance but not in type 2 diabetic patients.
Hernández-Alvarez MI, Chiellini C, Manco M, Naon D, Liesa M, Palacín M, Mingrone G, Zorzano A. Hernández-Alvarez MI, et al. Among authors: naon d. Diabetologia. 2009 Aug;52(8):1618-27. doi: 10.1007/s00125-009-1403-y. Epub 2009 Jun 6. Diabetologia. 2009. PMID: 19504086 Free article.
Subjects with early-onset type 2 diabetes show defective activation of the skeletal muscle PGC-1{alpha}/Mitofusin-2 regulatory pathway in response to physical activity.
Hernández-Alvarez MI, Thabit H, Burns N, Shah S, Brema I, Hatunic M, Finucane F, Liesa M, Chiellini C, Naon D, Zorzano A, Nolan JJ. Hernández-Alvarez MI, et al. Among authors: naon d. Diabetes Care. 2010 Mar;33(3):645-51. doi: 10.2337/dc09-1305. Epub 2009 Dec 23. Diabetes Care. 2010. PMID: 20032281 Free PMC article. Clinical Trial.
The promoter activity of human Mfn2 depends on Sp1 in vascular smooth muscle cells.
Sorianello E, Soriano FX, Fernández-Pascual S, Sancho A, Naon D, Vila-Caballer M, González-Navarro H, Portugal J, Andrés V, Palacín M, Zorzano A. Sorianello E, et al. Among authors: naon d. Cardiovasc Res. 2012 Apr 1;94(1):38-47. doi: 10.1093/cvr/cvs006. Epub 2012 Jan 17. Cardiovasc Res. 2012. PMID: 22253285 Free article.
Targeting the association of calgranulin B (S100A9) with insulin resistance and type 2 diabetes.
Ortega FJ, Mercader JM, Moreno-Navarrete JM, Sabater M, Pueyo N, Valdés S, Ruiz B, Luche E, Serino M, Naon D, Ricart W, Botas P, Delgado E, Burcelin R, Frühbeck G, Bosch F, Mingrone G, Zorzano A, Fernández-Real JM. Ortega FJ, et al. Among authors: naon d. J Mol Med (Berl). 2013 Apr;91(4):523-34. doi: 10.1007/s00109-012-0979-8. Epub 2012 Dec 4. J Mol Med (Berl). 2013. PMID: 23207880
Critical reappraisal confirms that Mitofusin 2 is an endoplasmic reticulum-mitochondria tether.
Naon D, Zaninello M, Giacomello M, Varanita T, Grespi F, Lakshminaranayan S, Serafini A, Semenzato M, Herkenne S, Hernández-Alvarez MI, Zorzano A, De Stefani D, Dorn GW 2nd, Scorrano L. Naon D, et al. Proc Natl Acad Sci U S A. 2016 Oct 4;113(40):11249-11254. doi: 10.1073/pnas.1606786113. Epub 2016 Sep 19. Proc Natl Acad Sci U S A. 2016. PMID: 27647893 Free PMC article.
Reply to Filadi et al.: Does Mitofusin 2 tether or separate endoplasmic reticulum and mitochondria?
Naon D, Zaninello M, Giacomello M, Varanita T, Grespi F, Lakshminaranayan S, Serafini A, Semenzato M, Herkenne S, Hernández-Alvarez MI, Zorzano A, De Stefani D, Dorn GW 2nd, Scorrano L. Naon D, et al. Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):E2268-E2269. doi: 10.1073/pnas.1618610114. Epub 2017 Mar 13. Proc Natl Acad Sci U S A. 2017. PMID: 28289205 Free PMC article. No abstract available.
Splice variants of mitofusin 2 shape the endoplasmic reticulum and tether it to mitochondria.
Naón D, Hernández-Alvarez MI, Shinjo S, Wieczor M, Ivanova S, Martins de Brito O, Quintana A, Hidalgo J, Palacín M, Aparicio P, Castellanos J, Lores L, Sebastián D, Fernández-Veledo S, Vendrell J, Joven J, Orozco M, Zorzano A, Scorrano L. Naón D, et al. Science. 2023 Jun 23;380(6651):eadh9351. doi: 10.1126/science.adh9351. Epub 2023 Jun 23. Science. 2023. PMID: 37347868
Cytoskeletal transgelin 2 contributes to gender-dependent adipose tissue expandability and immune function.
Ortega FJ, Moreno-Navarrete JM, Mercader JM, Gómez-Serrano M, García-Santos E, Latorre J, Lluch A, Sabater M, Caballano-Infantes E, Guzmán R, Macías-González M, Buxo M, Gironés J, Vilallonga R, Naon D, Botas P, Delgado E, Corella D, Burcelin R, Frühbeck G, Ricart W, Simó R, Castrillon-Rodríguez I, Tinahones FJ, Bosch F, Vidal-Puig A, Malagón MM, Peral B, Zorzano A, Fernández-Real JM. Ortega FJ, et al. Among authors: naon d. FASEB J. 2019 Aug;33(8):9656-9671. doi: 10.1096/fj.201900479R. Epub 2019 May 30. FASEB J. 2019. PMID: 31145872 Free article.
20 results