Nikaido H - Search Results

1

A periplasmic drug-binding site of the AcrB multidrug efflux pump: a crystallographic and site-directed mutagenesis study.

Yu EW, Aires JR, McDermott G, Nikaido H. Yu EW, et al. Among authors: nikaido h. J Bacteriol. 2005 Oct;187(19):6804-15. doi: 10.1128/JB.187.19.6804-6815.2005. J Bacteriol. 2005. PMID: 16166543 Free PMC article.

2

Structural basis of multiple drug-binding capacity of the AcrB multidrug efflux pump.

Yu EW, McDermott G, Zgurskaya HI, Nikaido H, Koshland DE Jr. Yu EW, et al. Among authors: nikaido h. Science. 2003 May 9;300(5621):976-80. doi: 10.1126/science.1083137. Science. 2003. PMID: 12738864

3

AcrB multidrug efflux pump of Escherichia coli: composite substrate-binding cavity of exceptional flexibility generates its extremely wide substrate specificity.

Yu EW, Aires JR, Nikaido H. Yu EW, et al. Among authors: nikaido h. J Bacteriol. 2003 Oct;185(19):5657-64. doi: 10.1128/JB.185.19.5657-5664.2003. J Bacteriol. 2003. PMID: 13129936 Free PMC article. Review. No abstract available.

4

Aminoglycosides are captured from both periplasm and cytoplasm by the AcrD multidrug efflux transporter of Escherichia coli.

Aires JR, Nikaido H. Aires JR, et al. Among authors: nikaido h. J Bacteriol. 2005 Mar;187(6):1923-9. doi: 10.1128/JB.187.6.1923-1929.2005. J Bacteriol. 2005. PMID: 15743938 Free PMC article.

5

Conformation of the AcrB multidrug efflux pump in mutants of the putative proton relay pathway.

Su CC, Li M, Gu R, Takatsuka Y, McDermott G, Nikaido H, Yu EW. Su CC, et al. Among authors: nikaido h. J Bacteriol. 2006 Oct;188(20):7290-6. doi: 10.1128/JB.00684-06. J Bacteriol. 2006. PMID: 17015668 Free PMC article.

6

Ligand-transporter interaction in the AcrB multidrug efflux pump determined by fluorescence polarization assay.

Su CC, Yu EW. Su CC, et al. FEBS Lett. 2007 Oct 16;581(25):4972-6. doi: 10.1016/j.febslet.2007.09.035. Epub 2007 Sep 25. FEBS Lett. 2007. PMID: 17910961 Free PMC article.

7

Reversal of the Drug Binding Pocket Defects of the AcrB Multidrug Efflux Pump Protein of Escherichia coli.

Soparkar K, Kinana AD, Weeks JW, Morrison KD, Nikaido H, Misra R. Soparkar K, et al. Among authors: nikaido h. J Bacteriol. 2015 Oct;197(20):3255-64. doi: 10.1128/JB.00547-15. Epub 2015 Aug 3. J Bacteriol. 2015. PMID: 26240069 Free PMC article.

8

Substrate specificity of the RND-type multidrug efflux pumps AcrB and AcrD of Escherichia coli is determined predominantly by two large periplasmic loops.

Elkins CA, Nikaido H. Elkins CA, et al. Among authors: nikaido h. J Bacteriol. 2002 Dec;184(23):6490-8. doi: 10.1128/JB.184.23.6490-6499.2002. J Bacteriol. 2002. PMID: 12426336 Free PMC article.

9

Chimeric analysis of AcrA function reveals the importance of its C-terminal domain in its interaction with the AcrB multidrug efflux pump.

Elkins CA, Nikaido H. Elkins CA, et al. Among authors: nikaido h. J Bacteriol. 2003 Sep;185(18):5349-56. doi: 10.1128/JB.185.18.5349-5356.2003. J Bacteriol. 2003. PMID: 12949086 Free PMC article.

10

Threonine-978 in the transmembrane segment of the multidrug efflux pump AcrB of Escherichia coli is crucial for drug transport as a probable component of the proton relay network.

Takatsuka Y, Nikaido H. Takatsuka Y, et al. Among authors: nikaido h. J Bacteriol. 2006 Oct;188(20):7284-9. doi: 10.1128/JB.00683-06. J Bacteriol. 2006. PMID: 17015667 Free PMC article.

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