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Delineation, functional validation, and bioinformatic evaluation of gene expression in thyroid follicular carcinomas with the PAX8-PPARG translocation.
Giordano TJ, Au AY, Kuick R, Thomas DG, Rhodes DR, Wilhelm KG Jr, Vinco M, Misek DE, Sanders D, Zhu Z, Ciampi R, Hanash S, Chinnaiyan A, Clifton-Bligh RJ, Robinson BG, Nikiforov YE, Koenig RJ. Giordano TJ, et al. Among authors: wilhelm kg jr. Clin Cancer Res. 2006 Apr 1;12(7 Pt 1):1983-93. doi: 10.1158/1078-0432.CCR-05-2039. Clin Cancer Res. 2006. PMID: 16609007
PAX8-peroxisome proliferator-activated receptor gamma (PPARgamma) disrupts normal PAX8 or PPARgamma transcriptional function and stimulates follicular thyroid cell growth.
Au AY, McBride C, Wilhelm KG Jr, Koenig RJ, Speller B, Cheung L, Messina M, Wentworth J, Tasevski V, Learoyd D, Robinson BG, Clifton-Bligh RJ. Au AY, et al. Among authors: wilhelm kg jr. Endocrinology. 2006 Jan;147(1):367-76. doi: 10.1210/en.2005-0147. Epub 2005 Sep 22. Endocrinology. 2006. PMID: 16179407