Replacements of single basic amino acids in the pleckstrin homology domain of phospholipase C-delta1 alter the ligand binding, phospholipase activity, and interaction with the plasma membrane.
Yagisawa H, Sakuma K, Paterson HF, Cheung R, Allen V, Hirata H, Watanabe Y, Hirata M, Williams RL, Katan M.
Yagisawa H, et al.
J Biol Chem. 1998 Jan 2;273(1):417-24. doi: 10.1074/jbc.273.1.417.
J Biol Chem. 1998.
PMID: 9417098
Free article.
We have previously identified a region rich in basic amino acids within the PH domain critical for ligand binding (Yagisawa, H., Hirata, M., Kanematsu, T., Watanabe, Y., Ozaki, S., Sakuma, K., Tanaka, H., Yabuta, N., Kamata, H., Hirata, H., and …
We have previously identified a region rich in basic amino acids within the PH domain critical for ligand binding (Yagisawa, H …