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The K121Q polymorphism of the ENPP1/PC-1 gene is associated with insulin resistance/atherogenic phenotypes, including earlier onset of type 2 diabetes and myocardial infarction.
Bacci S, Ludovico O, Prudente S, Zhang YY, Di Paola R, Mangiacotti D, Rauseo A, Nolan D, Duffy J, Fini G, Salvemini L, Amico C, Vigna C, Pellegrini F, Menzaghi C, Doria A, Trischitta V. Bacci S, et al. Among authors: di paola r. Diabetes. 2005 Oct;54(10):3021-5. doi: 10.2337/diabetes.54.10.3021. Diabetes. 2005. PMID: 16186408
A cluster of three single nucleotide polymorphisms in the 3'-untranslated region of human glycoprotein PC-1 gene stabilizes PC-1 mRNA and is associated with increased PC-1 protein content and insulin resistance-related abnormalities.
Frittitta L, Ercolino T, Bozzali M, Argiolas A, Graci S, Santagati MG, Spampinato D, Di Paola R, Cisternino C, Tassi V, Vigneri R, Pizzuti A, Trischitta V. Frittitta L, et al. Among authors: di paola r. Diabetes. 2001 Aug;50(8):1952-5. doi: 10.2337/diabetes.50.8.1952. Diabetes. 2001. PMID: 11473061
A variation in 3' UTR of hPTP1B increases specific gene expression and associates with insulin resistance.
Di Paola R, Frittitta L, Miscio G, Bozzali M, Baratta R, Centra M, Spampinato D, Santagati MG, Ercolino T, Cisternino C, Soccio T, Mastroianno S, Tassi V, Almgren P, Pizzuti A, Vigneri R, Trischitta V. Di Paola R, et al. Am J Hum Genet. 2002 Mar;70(3):806-12. doi: 10.1086/339270. Epub 2002 Feb 6. Am J Hum Genet. 2002. PMID: 11833006 Free PMC article.
718 results