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Page 1
Quantum model of catalysis based on a mobile proton revealed by subatomic x-ray and neutron diffraction studies of h-aldose reductase.
Blakeley MP, Ruiz F, Cachau R, Hazemann I, Meilleur F, Mitschler A, Ginell S, Afonine P, Ventura ON, Cousido-Siah A, Haertlein M, Joachimiak A, Myles D, Podjarny A. Blakeley MP, et al. Among authors: hazemann i. Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):1844-8. doi: 10.1073/pnas.0711659105. Epub 2008 Feb 4. Proc Natl Acad Sci U S A. 2008. PMID: 18250329 Free PMC article.
Incorporation of methyl-protonated valine and leucine residues into deuterated ocean pout type III antifreeze protein: expression, crystallization and preliminary neutron diffraction studies.
Petit-Haertlein I, Blakeley MP, Howard E, Hazemann I, Mitschler A, Podjarny A, Haertlein M. Petit-Haertlein I, et al. Among authors: hazemann i. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Jun 1;66(Pt 6):665-9. doi: 10.1107/S1744309110012352. Epub 2010 May 26. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010. PMID: 20516595 Free PMC article.
Neutron macromolecular crystallography with LADI-III.
Blakeley MP, Teixeira SC, Petit-Haertlein I, Hazemann I, Mitschler A, Haertlein M, Howard E, Podjarny AD. Blakeley MP, et al. Among authors: hazemann i. Acta Crystallogr D Biol Crystallogr. 2010 Nov;66(Pt 11):1198-205. doi: 10.1107/S0907444910019797. Epub 2010 Oct 20. Acta Crystallogr D Biol Crystallogr. 2010. PMID: 21041937
Crystal packing modifies ligand binding affinity: the case of aldose reductase.
Cousido-Siah A, Petrova T, Hazemann I, Mitschler A, Ruiz FX, Howard E, Ginell S, Atmanene C, Van Dorsselaer A, Sanglier-Cianférani S, Joachimiak A, Podjarny A. Cousido-Siah A, et al. Among authors: hazemann i. Proteins. 2012 Nov;80(11):2552-61. doi: 10.1002/prot.24136. Epub 2012 Jul 28. Proteins. 2012. PMID: 22752989 Free PMC article.
Factorizing selectivity determinants of inhibitor binding toward aldose and aldehyde reductases: structural and thermodynamic properties of the aldose reductase mutant Leu300Pro-fidarestat complex.
Petrova T, Steuber H, Hazemann I, Cousido-Siah A, Mitschler A, Chung R, Oka M, Klebe G, El-Kabbani O, Joachimiak A, Podjarny A. Petrova T, et al. Among authors: hazemann i. J Med Chem. 2005 Sep 8;48(18):5659-65. doi: 10.1021/jm050424+. J Med Chem. 2005. PMID: 16134934
The atomic resolution structure of human aldose reductase reveals that rearrangement of a bound ligand allows the opening of the safety-belt loop.
Biadene M, Hazemann I, Cousido A, Ginell S, Joachimiak A, Sheldrick GM, Podjarny A, Schneider TR. Biadene M, et al. Among authors: hazemann i. Acta Crystallogr D Biol Crystallogr. 2007 Jun;63(Pt 6):665-72. doi: 10.1107/S0907444907011997. Epub 2007 May 15. Acta Crystallogr D Biol Crystallogr. 2007. PMID: 17505104
32 results